1H-Benzimidazole-5-carboxylic acid
- Product Name
- 1H-Benzimidazole-5-carboxylic acid
- CAS No.
- 15788-16-6
- Chemical Name
- 1H-Benzimidazole-5-carboxylic acid
- Synonyms
- 1H-benzo[d]iMidazole-5-carboxylic acid;1H-Benzo[d]iMidazole-6-carboxylic acid;5-BENZIMIDAZOLECARBOXYLIC ACID;AURORA 9842;AKOS BBS-00000435;BenziMidazole-5-acid;OTAVA-BB BB7014211630;5-CARBOXYBENZIMIDAZOLE;4-caboxylic benzimidazole;5-caboxylic benziMidazole
- CBNumber
- CB6435996
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 15788-16-6.mol
1H-Benzimidazole-5-carboxylic acid Property
- Melting point:
- >300 °C (lit.)
- Boiling point:
- 288.82°C (rough estimate)
- Density
- 1.3264 (rough estimate)
- refractive index
- 1.5770 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Powder
- pka
- 3.10±0.30(Predicted)
- color
- Green-gray to gray-brown
- BRN
- 5686
- InChI
- InChI=1S/C8H6N2O2/c11-8(12)5-1-2-6-7(3-5)10-4-9-6/h1-4H,(H,9,10)(H,11,12)
- InChIKey
- COYPLDIXZODDDL-UHFFFAOYSA-N
- SMILES
- C1NC2=CC(C(O)=O)=CC=C2N=1
- CAS DataBase Reference
- 15788-16-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 296783
- Product name
- 5-Benzimidazolecarboxylic acid
- Purity
- 96%
- Packaging
- 5g
- Price
- $60.8
- Updated
- 2025/07/31
- Product number
- 296783
- Product name
- 5-Benzimidazolecarboxylic acid
- Purity
- 96%
- Packaging
- 25g
- Price
- $266
- Updated
- 2025/07/31
- Product number
- B1763
- Product name
- 5-Benzimidazolecarboxylic Acid
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- B1763
- Product name
- 5-Benzimidazolecarboxylic Acid
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $275
- Updated
- 2025/07/31
- Product number
- CHM0017992
- Product name
- 1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1166.55
- Updated
- 2021/12/16
1H-Benzimidazole-5-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
GREEN-GREY TO GREY-BROWN POWDER
Uses
A benzimidazole derivative that exhibits corrosion inhibiting properties against strong acids.
Uses
5-Benzimidazolecarboxylic acid has been used in the preparation of:
- 1H-benzoimidazole-5-carboxylic acid benzotriazol-1-yl ester
- piperidin-1-yl(1-m-tolyl-1H-benzo[d]imidazol-5-yl)methanone
General Description
Drug-specific monoclonal antibodies were produced against the very small drug hapten, 5-benzimidazolecarboxylic acid.
Synthesis
124-38-9
4887-88-1
15788-16-6
To a solution of 5-bromo-1H-benzimidazole (0.87 g, 4.4 mmol, 1.0 eq.) in anhydrous THF (20 mL) was slowly added 2 M isopropylmagnesium chloride (i-PrMgCl) in a solution of THF (2.2 mL, 4.4 mmol, 1.0 eq.) at 0 °C, keeping the reaction temperature not more than 20 °C. After addition, the clarified solution was continued to be stirred at 0 °C for 5 min. Subsequently, 2.5 M hexane solution (3.5 mL, 8.8 mmol, 2.0 eq.) of n-butyllithium (n-BuLi) was added dropwise over 5 min, controlling the temperature below 20 °C. The reaction mixture was stirred at the same temperature for 30 min. Then, dry carbon dioxide (0.20 g, 4.4 mmol, 1.0 eq.) was added to the reaction system and the mixture was slowly warmed to 20 °C over 30 min. Upon completion of the reaction, the reaction was quenched with deionized water (6 mL). After stirring at 20 °C for 10 min, the organic and aqueous phases were separated. The aqueous phase was extracted once with ethyl acetate (10 mL). The organic phases were combined, filtered through a 0.51 cm silica gel pad and eluted with ethyl acetate (10 mL). The filtrate was concentrated and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 3:1) to afford 1H-benzimidazole-5-carboxylic acid (0.5 g, 71% yield) as a brown solid. The product was structurally confirmed by 1H-NMR (600 MHz, DMSO-d6) and 13C-NMR (151 MHz, DMSO-d6).
References
[1] Molecules, 2017, vol. 22, # 11,
1H-Benzimidazole-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Benzimidazole-5-carboxylic acid Suppliers
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View Lastest Price from 1H-Benzimidazole-5-carboxylic acid manufacturers
- Product
- 1H-Benzimidazole-5-carboxylic acid 15788-16-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.3%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- 1H-Benzimidazole-5-carboxylic acid 15788-16-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04