SAfit2
- Product Name
- SAfit2
- CAS No.
- 1643125-33-0
- Chemical Name
- SAfit2
- Synonyms
- SAfit2;SAFit2, 10 mM in DMSO;(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate;(1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate;2-Piperidinecarboxylic acid, 1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester, (2S)-
- CBNumber
- CB64666288
- Molecular Formula
- C46H62N2O10
- Formula Weight
- 802.99
- MOL File
- 1643125-33-0.mol
SAfit2 Property
- Boiling point:
- 877.0±65.0 °C(Predicted)
- Density
- 1.168±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 6.43±0.10(Predicted)
- color
- Off-white to pink
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 24366
- Product name
- SAfit2
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 24366
- Product name
- SAfit2
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 24366
- Product name
- SAfit2
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $830
- Updated
- 2024/03/01
- Product number
- S139585
- Product name
- SAFit2
- Packaging
- 5mg
- Price
- $2085
- Updated
- 2021/12/16
- Product number
- CS-0022959
- Product name
- SAFit2
- Purity
- 98.59%
- Packaging
- 25mg
- Price
- $1050
- Updated
- 2021/12/16
SAfit2 Chemical Properties,Usage,Production
Description
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; Ki = 6 nM). It is highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; ). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.
Uses
SAFit2 is a highly selective inhibitor of FKBP51. The selective inhibition of FKBP51, using SAFit1(S139583) & SAFit2 , has shown to enhances neurite elongation in neuronal cultures and improves neuroendocrine feedback and stress-coping behavior in mice.
SAfit2 Preparation Products And Raw materials
Raw materials
Preparation Products
SAfit2 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81