TES-991
- Product Name
- TES-991
- CAS No.
- 1883602-20-7
- Chemical Name
- TES-991
- Synonyms
- TES-991;TES991,TES 991;5-Pyrimidinecarbonitrile, 1,6-dihydro-6-oxo-2-[[[3-(2H-tetrazol-5-yl)phenyl]methyl]thio]-4-(2-thienyl)-
- CBNumber
- CB64797102
- Molecular Formula
- C17H11N7OS2
- Formula Weight
- 393.45
- MOL File
- 1883602-20-7.mol
TES-991 Property
- Boiling point:
- 656.7±65.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 62.5 mg/mL (158.85 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 4.18±0.10(Predicted)
- color
- Light yellow to yellow
TES-991 Chemical Properties,Usage,Production
Uses
TES-991 is a potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM.
in vivo
After the intravenous administration of 0.5 mg/kg, TES-991 (compound 21) shows low blood clearance, with low volumes of distribution and halflives (t1/2) of about 4.0 and 5.0 h, respectively, although after oral administration at 5 mg/kg, the blood concentrations of TES-991 is quantifiable for up to 8 h. A moderate systemic exposure is observed for the 2H-tetrazole analogue, TES-991, a good systemic exposure is recorded for the free acid[1].
References
[1] Pellicciari R, et al. α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61(3):745-759. DOI:10.1021/acs.jmedchem.7b01254
TES-991 Preparation Products And Raw materials
Raw materials
Preparation Products
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