ChemicalBook > CAS DataBase List > guselkumab
guselkumab
- Product Name
- guselkumab
- CAS No.
- 1350289-85-8
- Chemical Name
- guselkumab
- Synonyms
- CNTO 1959;guselkumab;Guselkumab (anti-IL-23);Research Grade Guselkumab;Research Grade Guselkumab(DHJ63103)
- CBNumber
- CB64919948
- Formula Weight
- 0
- MOL File
- Mol file
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guselkumab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
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guselkumab Chemical Properties,Usage,Production
Uses
Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research[1].
IC 50
IL-23: .06 nM (IC50)
References
[1] International non-proprietary name: guselkumab Procedure No. EMEA/H/C/004271/0000par-public-assessment-report_en.pdf
[2] Li Li, et al. IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis. Int Immunopharmacol DOI:10.1016/j.intimp.2020.107008
guselkumab Preparation Products And Raw materials
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