ChemicalBook > CAS DataBase List > Vodobatinib

Vodobatinib

Product Name: Vodobatinib
CAS No.: 1388803-90-4
Chemical Name: Vodobatinib
Synonyms: Vodobatinib;Vodobatinib (K0706);Vodobatinib (K0706) ，E0047;Vodobatinib, 10 mM in DMSO;Vodobatinib (SCO-088, SUN-K706;2-Chloro-6-methyl-N'-(4-methyl-3-(quinolin-3-ylethynyl)benzoyl)benzohydrazide;N'-(2-chloro-6-methylbenzoyl)-4-methyl-3-[2-(3-quinolyl)ethynyl]-benzohydrazide;myeloid,Inhibitor,inhibit,Vodobatinib,chronic,K0706,Bcr-Abl,K 0706,Bcr-Abl1,leukemia,TKI;Benzoic acid, 2-chloro-6-methyl-, 2-[4-methyl-3-[2-(3-quinolinyl)ethynyl]benzoyl]hydrazide
CBNumber: CB65832198
Molecular Formula: C27H20ClN3O2
Formula Weight: 453.92
MOL File: 1388803-90-4.mol

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Vodobatinib Property

Boiling point:: 748.6±60.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (275.38 mM; Need ultrasonic)
pka: 10.09±0.23(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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Vodobatinib Chemical Properties,Usage,Production

Uses

Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic myeloid leukemia (CML) research[1][2]. Vodobatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

BCR-ABL1: 7 nM (IC₅₀)

References

[1] Orlando Antelope, et al. BCR-ABL1 tyrosine kinase inhibitor K0706 exhibits preclinical activity in Philadelphia chromosome-positive leukemia. Exp Hematol. 2019 Sep;77:36-40.e2. DOI:10.1016/j.exphem.2019.08.007
[2] Phase 1 Trial of Vodobatinib, a Novel Oral BCR-ABL1 Tyrosine Kinase Inhibitor (TKI): Activity in CML Chronic Phase Patients Failing TKI Therapies Including Ponatinib. Session: 632: Chronic Myeloid Leukemia: Therapy: CML: New and Beyond.

Vodobatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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1388803-90-4, VodobatinibRelated Search:

2-Chloro-6-methyl-N'-(4-methyl-3-(quinolin-3-ylethynyl)benzoyl)benzohydrazide

Benzoic acid, 2-chloro-6-methyl-, 2-[4-methyl-3-[2-(3-quinolinyl)ethynyl]benzoyl]hydrazide

N'-(2-chloro-6-methylbenzoyl)-4-methyl-3-[2-(3-quinolyl)ethynyl]-benzohydrazide

Vodobatinib

Vodobatinib (SCO-088, SUN-K706

Vodobatinib (K0706)

myeloid,Inhibitor,inhibit,Vodobatinib,chronic,K0706,Bcr-Abl,K 0706,Bcr-Abl1,leukemia,TKI

Vodobatinib, 10 mM in DMSO

Vodobatinib (K0706) ，E0047

1388803-90-4