ChemicalBook > CAS DataBase List > (+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1

(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1

Product Name
(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1
CAS No.
433219-55-7
Chemical Name
(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1
Synonyms
BUTAPROST (FREE ACID);(R)-BUTAPROST (FREE ACID);(S)-Butaprost (free acid);PAYNQYXOKJDXAV-ZHIWTBQHSA-N;(+/-)-15-DEOXY-16S-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1;(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1;9-OXO-11ALPHA, 16R-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID;9-OXO-11ALPHA, 16S-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID;Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4S)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, (1R,2R,3R)-
CBNumber
CB6711207
Molecular Formula
C23H38O5
Formula Weight
394.54
MOL File
433219-55-7.mol
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(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1 Property

storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMSO: 25/mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 100 μg/ml
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13741
Product name
Butaprost (free acid)
Purity
≥95%
Packaging
500μg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
13741
Product name
Butaprost (free acid)
Purity
≥95%
Packaging
1mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
13741
Product name
Butaprost (free acid)
Purity
≥95%
Packaging
5mg
Price
$826
Updated
2024/03/01
Cayman Chemical
Product number
13741
Product name
Butaprost (free acid)
Purity
≥95%
Packaging
10mg
Price
$1444
Updated
2024/03/01
AK Scientific
Product number
1028AH
Product name
(+/-)-15-Deoxy-16R-Hydroxy-17-cyclobutylprostaglandinE1
Packaging
10mg
Price
$1706
Updated
2021/12/16
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(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1 Chemical Properties,Usage,Production

Description

Butaprost is an EP2 selective agonist which has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.1,2 Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. Consistent with this trend, butaprost binds to membranes from EP2 receptor-transfected CHO cells with a Ki value of 2,400 nM, whereas butaprost (free acid) and CAY10399 (the 2-series congener of butaprost free acid) exhibit significantly lower Ki values of 73 and 92 nM, respectively.3 Butaprost (free acid) is therefore another useful tool for characterizing EP receptor-mediated signalling events.

Uses

(S)-Butaprost (free acid) is a potent and highly selective agonist of EP2 receptor[1].

References

1. Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells Br. J. Pharmacol. 122(2),217-224(1997).
2. Lawrence, R.A., and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein Br. J. Pharmacol. 105,817-824(1992).
3. Tani, K., Naganawa, A., Ishida, A., et al. Design and synthesis of a highly selective EP2-receptor agonist Bioorg. Med. Chem. Lett. 11,2025-2028(2001).

(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1 Suppliers

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433219-55-7, (+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1Related Search:

(+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1 (R)-BUTAPROST

  • (R)-BUTAPROST (FREE ACID)
  • BUTAPROST (FREE ACID)
  • 9-OXO-11ALPHA, 16S-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID
  • 9-OXO-11ALPHA, 16R-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID
  • (+/-)-15-DEOXY-16R-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1
  • (+/-)-15-DEOXY-16S-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1
  • PAYNQYXOKJDXAV-ZHIWTBQHSA-N
  • Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4S)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, (1R,2R,3R)-
  • (S)-Butaprost (free acid)
  • 433219-55-7