TASIN-1 hydrochloride

Product Name: TASIN-1 hydrochloride
CAS No.: 1678515-13-3
Chemical Name: TASIN-1 hydrochloride
Synonyms: TASIN1 HCl;TASIN 1 HCl;TASIN-1 HCl;TASIN-1 hydrochloride;TASIN-1 hydrochloride >=98% (HPLC);TASIN-1 Hydrochloride, 10 mM in DMSO;TASIN 1 Hydrochloride,TASIN1 Hydrochloride
CBNumber: CB67245941
Molecular Formula: C18H29ClN2O3S
Formula Weight: 388.95
MOL File: 1678515-13-3.mol

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TASIN-1 hydrochloride Property

storage temp.: -20°C
solubility: Soluble in DMSO (20 mg/ml)
form: solid
color: White to off-white
Water Solubility: H2O: 2mg/mL, clear
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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TASIN-1 hydrochloride Chemical Properties,Usage,Production

Description

TASIN-1 (1678515-13-3) selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line.? It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer.? TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2

References

Zhang et al. (2016), Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer; Sci. Transl. Med., 8 361ra140 Zhang et al. (2016), Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells; Mol. Cancer Ther., 17 943

TASIN-1 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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TASIN-1 hydrochloride Suppliers

CHINA 10 United States 3 Global 13

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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ShangHai ChuanQian Chemcial Technique Centre

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Energy Chemical

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Changzhou Furuisi Biotechnology Co., Ltd

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InvivoChem

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TargetMol Chemicals Inc.

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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

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Absin Bioscience Inc.

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Proteintech China

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1678515-13-3, TASIN-1 hydrochlorideRelated Search:

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TASIN-1 hydrochloride

TASIN-1 hydrochloride >=98% (HPLC)

TASIN 1 HCl

TASIN1 HCl

TASIN-1 HCl

TASIN 1 Hydrochloride,TASIN1 Hydrochloride

TASIN-1 Hydrochloride, 10 mM in DMSO

1678515-13-3