TASIN-1 hydrochloride Property

storage temp. 

-20°C

solubility 

Soluble in DMSO (20 mg/ml)

form 

solid

color 

White to off-white

Water Solubility 

H2O: 2mg/mL, clear

Stability:

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Hazard and Precautionary Statements (GHS)

TASIN-1 hydrochloride Chemical Properties,Usage,Production

Description

TASIN-1 (1678515-13-3) selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line.? It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer.? TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2

References

Zhang et al. (2016), Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer; Sci. Transl. Med., 8 361ra140 Zhang et al. (2016), Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells; Mol. Cancer Ther., 17 943