Fenoldopam
- Product Name
- Fenoldopam
- CAS No.
- 67227-56-9
- Chemical Name
- Fenoldopam
- Synonyms
- CS-1332;Corlopam;SKF-82526;FENOLDOPAM;SKF-82526-J;CORLOPAM MESYLATE;Fenoldopam, Corlopam;Fenoldopam USP/EP/BP;Fenoldopam hydrochlo;FenoldopamMesylateBase
- CBNumber
- CB6729842
- Molecular Formula
- C16H16ClNO3
- Formula Weight
- 305.76
- MOL File
- 67227-56-9.mol
Fenoldopam Property
- Boiling point:
- 522.6±50.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >12 mg/mL
- pka
- 8.50±0.40(Predicted)
- form
- Powder
- color
- off-white
- InChI
- InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
- InChIKey
- TVURRHSHRRELCG-UHFFFAOYSA-N
- SMILES
- N1CCC2=C(Cl)C(O)=C(O)C=C2C(C2=CC=C(O)C=C2)C1
- CAS DataBase Reference
- 67227-56-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36-42/43
- Safety Statements
- 22-26-36/37/39
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 1659
- Product name
- Fenoldopamhydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 1659
- Product name
- Fenoldopamhydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $818
- Updated
- 2021/12/16
- Product number
- 011983
- Product name
- Fenoldopam
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- 011985
- Product name
- Fenoldopam Hydrochloride
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- I745
- Product name
- Fenoldopam
- Packaging
- 10mg
- Price
- $229
- Updated
- 2021/12/16
Fenoldopam Chemical Properties,Usage,Production
Chemical Properties
Fenoldopam Hydrobromide: C16H16C1NO3/HBr. Melting point: 277°C (decomposition). Fenoldopam Mesylate: C16H16C1NO3/CH3SO3. [67227-57-0]. Melting point: 274°C (decomposition).
Originator
Corlopam,Pharmaforce, Inc.
Uses
Dopamine D1-receptor agonist. Antihypertensive.
Uses
dopamine receptor agonists
Uses
The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Fenoldopam is a selective dopamine 1 receptor agonist with diuretic and properties (2,3).
Definition
ChEBI: Fenoldopam is a benzazepine. It has a role as a dopaminergic antagonist, a vasodilator agent, an alpha-adrenergic agonist, a dopamine agonist and an antihypertensive agent.
Manufacturing Process
2-Chloro-3,4-dimethoxyphenethylamine (1.0 g) was reacted with 0.70 g of pmethoxystyrene
oxide to give the hydroxyphenethylamine; m.p. 118.5-121°C.
This compound (2.16 g) was stirred at room temperature in 15 ml of
trifluoroacetic acid with 4 drops of conc. sulfuric acid. After purification over a
silica gel column with chloroform, 10% methanol/chloroform as eluates, was
obtained 6-chloro-7,8-dimethoxy-1-p-methoxyphenyl-2,3,4,5-tetrahydro-1H-
3-benzazepine (0.78 g), m.p. 143-145°C.
The trimethoxy product (0.87 g, 2.50 mmoles) in 25 ml of dry methylene
chloride was cooled in an ice-methanol bath and 12.5 ml (25.0 mmoles) of
boron tribromide in methylene chloride was added dropwise. After stirring for
4 hours, the mixture was cooled in an ice bath while methanol was carefully
added to give 0.37 g of 6-chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-
tetrahydro-1H-3-benzazepine hydrobromide, m.p. 215°C.
The base was regenerated from the hydrobromide salt using sodium carbonate solution in 85% yield. Treating the base with various acids gave the
following salts: dl-tartrate, fumarate, hydrochloride, sulfate, and the most
water soluble one, the methanesulfonate, m.p. 272°C.
brand name
Corlopam (Hospira).
Therapeutic Function
Antihypertensive
Biological Activity
Selective D 1 -like dopamine receptor partial agonist (EC 50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α 2 -adrenoceptor antagonist in vitro (K i = 15-25 nM).
Fenoldopam Preparation Products And Raw materials
Raw materials
Preparation Products
Fenoldopam Suppliers
- Tel
- 571-88199336 18957129209
- Fax
- 0571-88190523
- 309645123@qq.com
- Country
- China
- ProdList
- 53
- Advantage
- 64
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3506
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6468
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13305
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@MedChemLeader.com
- Country
- China
- ProdList
- 1006
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +86-029-89586680 +86-18192503167
- Fax
- +86-29-88380327
- 1026@dideu.com
- Country
- China
- ProdList
- 8025
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49975
- Advantage
- 58
- Tel
- 13163333255
- 1939328613@qq.com
- Country
- China
- ProdList
- 395
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 15921930842 15921930842
- yh-wang@univ-bio.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 0573-85866609 13588473046
- 824930988@qq.com
- Country
- China
- ProdList
- 7865
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 5002
- Advantage
- 58
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 29423
- Advantage
- 58
- Tel
- 4008-099-669
- 23419001name@qq.com
- Country
- CHINA
- ProdList
- 6043
- Advantage
- 58
- Tel
- 400-025-6535
- sales@adooq.cn
- Country
- China
- ProdList
- 6215
- Advantage
- 58
- Tel
- 400-668-6834
- info@selleck.cn
- Country
- China
- ProdList
- 6071
- Advantage
- 58
- Tel
- 021-60936350
- scbt@scbt.com
- Country
- China
- ProdList
- 6594
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- sales@coreychem.com
- Country
- China
- ProdList
- 29847
- Advantage
- 58
- Tel
- +8618058761490
- info@gihichemicals.com
- Country
- China
- ProdList
- 49941
- Advantage
- 58
- Tel
- 19928332050
- Country
- CHINA
- ProdList
- 161
- Advantage
- 58
- Tel
- 057186405477
- Country
- CHINA
- ProdList
- 184
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@synniken.com
- Country
- China
- ProdList
- 135
- Advantage
- 38
- Tel
- --
- Fax
- --
- sales@etrustin.com
- Country
- China
- ProdList
- 5406
- Advantage
- 51
- Tel
- --
- Fax
- --
- sinowall@sohu.com
- Country
- China
- ProdList
- 112
- Advantage
- 42
- Tel
- --
- Fax
- --
- Country
- China
- ProdList
- 72
- Advantage
- 47
- Tel
- --
- Fax
- --
- info@inter-chemical.com
- Country
- China
- ProdList
- 253
- Advantage
- 42
- Tel
- --
- Fax
- --
- pharmasi@gmail.com
- Country
- China
- ProdList
- 268
- Advantage
- 43
- Tel
- --
- Fax
- --
- sinowall@sohu.com
- Country
- China
- ProdList
- 116
- Advantage
- 56
- Tel
- --
- Fax
- --
- service@verychem.com
- Country
- China
- ProdList
- 528
- Advantage
- 51
- Tel
- --
- Fax
- --
- sales@%20haoyu%20chem.com
- Country
- China
- ProdList
- 24
- Advantage
- 43
- Tel
- --
- Fax
- --
- contact@hanweichem.com
- Country
- China
- ProdList
- 28
- Advantage
- 43
- Tel
- --
- Fax
- --
- epochbiopharm@yahoo.com
- Country
- China
- ProdList
- 70
- Advantage
- 34
View Lastest Price from Fenoldopam manufacturers
- Product
- Fenoldopam 67227-56-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09
- Product
- Fenoldopam 67227-56-9
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20