Zalifrelimab

Product Name: Zalifrelimab
CAS No.: 2148321-69-9
Chemical Name: Zalifrelimab
Synonyms: Zalifrelimab;Zalifrelimab (anti-CTLA-4);Research Grade Zalifrelimab;Research Grade Zalifrelimab (DHD17202)
CBNumber: CB68081139
Formula Weight: 0
MOL File: Mol file

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Zalifrelimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Zalifrelimab Chemical Properties,Usage,Production

Uses

Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling[1].

in vivo

Zalifrelimab (AGEN1884; 10 mg/kg; i.v.; on days 1 and 29) is well-tolerated in non-human primates and enhances vaccine-mediated antigen-specific immunity^[2].

Animal Model:	Cynomolgus macaques (Macaca fascicularis)^[2]
Dosage:	10 mg/kg
Administration:	i.v.; on days 1 and 29
Result:	Enhanced antigen-specific immune responses in combination with reporter vaccines in vivo.

References

[1] David M O'Malley, et al. Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study. J Clin Oncol. 2022 Mar 1;40(7):762-771. DOI:10.1200/JCO.21.02067
[2] Randi B Gombos, et al. Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. PLoS One. 2018 Apr 4;13(4):e0191926. DOI:10.1371/journal.pone.0191926

Zalifrelimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Zalifrelimab Suppliers

China 13 Global 13

Shanghai YuanYe Biotechnology Co., Ltd.

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Atagenix Laboratories

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2148321-69-9, ZalifrelimabRelated Search:

Immunoglobulin G1,anti-(human NCA-90 granulocyte cell antigen) (mouse monoclonal IMMU-MN3 g1-chain), disulfide with mousemonoclonal IMMU-MN3 k-chain, dimer (9CI) Budigalimab Tozorakimab Carotuximab Timolumab Nirsevimab Tarcocimab Pidilizumab Porgaviximab Navicixizumab

Zalifrelimab

Research Grade Zalifrelimab (DHD17202)

Research Grade Zalifrelimab

Zalifrelimab (anti-CTLA-4)

2148321-69-9