4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-

Product Name: 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-
CAS No.: 2590556-80-0
Chemical Name: 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-
Synonyms: M4205;Velzatinib;M4205（IDRX-42）;M4205, 10 mM in DMSO;factor,M-4205,receptor,M4205,cell,CD117,growth,inhibit,mast/stem,mutations,SCFR,c-Kit,M 4205,Inhibitor;N-(4-(1-Methyl-1H-pyrazol-4-yl)benzyl)-6-(7-(3-(pyrrolidin-1-yl)propoxy)imidazo[1,2-a]pyridin-3-yl)pyrimidin-4-amine;N-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine;N-[[4-(1-Methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-4-pyrimidinamine;4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-
CBNumber: CB68988841
Molecular Formula: C29H32N8O
Formula Weight: 508.62
MOL File: 2590556-80-0.mol

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4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]- Property

Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 11.11 mg/mL (21.84 mM; ultrasonic and warming and heat to 66°C)
pka: 10.01±0.20(Predicted)
form: Solid
color: White to light brown

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Hazard and Precautionary Statements (GHS)

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4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]- Chemical Properties,Usage,Production

Uses

M4205 is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. M4205 exhibits antitumor efficacy in xenograft mouse models[1].

in vivo

M4205 (35 mg/kg for 30 days) exhibits antitumor efficacy in xenograft mouse models^[1].

Animal Model:	GIST430/654 xenograft models^[1].
Dosage:	35 mg/kg
Administration:	30 days
Result:	Inhibited tumor growth.

IC 50

PDGFRβ: 2.6 nM (IC₅₀); CSF1R: 5.5 nM (IC₅₀); KIT: 44 nM (IC₅₀); PDGFRA: 50 nM (IC₅₀); Lck: 141 nM (IC₅₀); FLT3: 141 nM (IC₅₀)

References

[1] Blum A, et al. Identification of M4205─ A highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors[J]. Journal of Medicinal Chemistry, 2023, 66(4): 2386-2395.

4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]- Suppliers

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2590556-80-0, 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-Related Search:

4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-

M4205

factor,M-4205,receptor,M4205,cell,CD117,growth,inhibit,mast/stem,mutations,SCFR,c-Kit,M 4205,Inhibitor

N-[[4-(1-Methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-4-pyrimidinamine

N-(4-(1-Methyl-1H-pyrazol-4-yl)benzyl)-6-(7-(3-(pyrrolidin-1-yl)propoxy)imidazo[1,2-a]pyridin-3-yl)pyrimidin-4-amine

M4205, 10 mM in DMSO

N-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine

M4205（IDRX-42）

Velzatinib

2590556-80-0