Valspodar

ChemicalBook > CAS DataBase List > Valspodar

Product Name: Valspodar
CAS No.: 121584-18-7
Chemical Name: Valspodar
Synonyms: Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
CBNumber: CB71116624
Molecular Formula: C63H111N11O12
Formula Weight: 1214.62
MOL File: 121584-18-7.mol

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Valspodar Property

Melting point:: 143-145°C
Boiling point:: 1290.1±65.0 °C(Predicted)
alpha: D20 -255.1° (c = 0.5 in CHCl3)
Density: 1.015±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder
pka: 12.45±0.70(Predicted)
color: white to beige
InChIKey: YJDYDFNKCBANTM-QCWCSKBGSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0572
Product name: Valspodar
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $189
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0572
Product name: Valspodar
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $741
Updated: 2024/03/01

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 500μg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 5 mg
Price: $184
Updated: 2024/03/01

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Valspodar Chemical Properties,Usage,Production

Description

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [¹⁴C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

Chemical Properties

White Solid

Uses

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Uses

Valspodar(PSC-833), a 2nd-generation ABC transporter inhibitor, limits HCMV infection as demonstrated by the decrease in IE2 expression of virus-infected cells. As a cyclosporin D analog, it has been shown to be a much more effective inhibitor of MDR than cyclosporin A and to be less toxic[1-2].

Uses

Antineoplastic adjunct (chemosensitizer).

Definition

ChEBI: SDZ PSC 833 is a homodetic cyclic peptide.

brand name

Amdray (Novartis).

Biochem/physiol Actions

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Cytotoxicity

Cells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].

storage

Store at -20°C

References

[1] Friedenberg W, et al. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95). Cancer, 2006; 106: 830-838.
[2] Parsons J, et al. Valspodar limits human cytomegalovirus infection and dissemination. Antiviral Research, 2021; 193: 105124.

Valspodar Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Valspodar manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Valspodar 121584-18-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Valspodar 121584-18-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

121584-18-7, ValspodarRelated Search:

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Valspodar

3'-Keto-bmt(1)-Val(2)-cyclosporin a

Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-

Psc 833

Sdz psc 833

Sdz-psc-833

Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]

6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA

Valspodar(PSC-833,AMdray)

6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D

6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A

AMdray

Valpodar

PSC833(Valspodar)

Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine-

Valspodar (PSC-833)

[3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin

6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D

PSC833 - Specific MDR1/P-gp Inhibitor

Valspodar, >=98%

CS-51

PSC 833; PSC-833; PSC833

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-6,9,18,24-Tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhex-4-enoyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

121584-18-7

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