ChemicalBook > CAS DataBase List > Valspodar

Valspodar

Product Name
Valspodar
CAS No.
121584-18-7
Chemical Name
Valspodar
Synonyms
Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
CBNumber
CB71116624
Molecular Formula
C63H111N11O12
Formula Weight
1214.62
MOL File
121584-18-7.mol
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Valspodar Property

Melting point:
143-145°C
Boiling point:
1290.1±65.0 °C(Predicted)
alpha 
D20 -255.1° (c = 0.5 in CHCl3)
Density 
1.015±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.45±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0572
Product name
Valspodar
Purity
≥98% (HPLC)
Packaging
5mg
Price
$184
Updated
2023/01/07
Sigma-Aldrich
Product number
SML0572
Product name
Valspodar
Purity
≥98% (HPLC)
Packaging
25mg
Price
$723
Updated
2023/01/07
Cayman Chemical
Product number
20391
Product name
PSC 833
Purity
≥95%
Packaging
500μg
Price
$25
Updated
2023/01/06
Cayman Chemical
Product number
20391
Product name
PSC 833
Purity
≥95%
Packaging
1mg
Price
$48
Updated
2023/01/06
Cayman Chemical
Product number
20391
Product name
PSC 833
Purity
≥95%
Packaging
5 mg
Price
$163
Updated
2023/01/06
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Valspodar Chemical Properties,Usage,Production

Description

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

Chemical Properties

White Solid

Uses

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Uses

Antineoplastic adjunct (chemosensitizer).

brand name

Amdray (Novartis).

Biochem/physiol Actions

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Valspodar Preparation Products And Raw materials

Raw materials

Preparation Products

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Valspodar Suppliers

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View Lastest Price from Valspodar manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Valspodar 121584-18-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Valspodar 121584-18-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

121584-18-7, ValspodarRelated Search:

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  • Valspodar
  • 3'-Keto-bmt(1)-Val(2)-cyclosporin a
  • Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-
  • Psc 833
  • Sdz psc 833
  • Sdz-psc-833
  • Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]
  • 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA
  • Valspodar(PSC-833,AMdray)
  • 6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D
  • 6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A
  • AMdray
  • Valpodar
  • PSC833(Valspodar)
  • Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine-
  • Valspodar (PSC-833)
  • [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin
  • 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D
  • PSC833 - Specific MDR1/P-gp Inhibitor
  • Valspodar, >=98%
  • CS-51
  • PSC 833; PSC-833; PSC833
  • 121584-18-7
  • Intermediates & Fine Chemicals
  • Peptides
  • Pharmaceuticals