Valspodar

Product Name: Valspodar
CAS No.: 121584-18-7
Chemical Name: Valspodar
Synonyms: Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
CBNumber: CB71116624
Molecular Formula: C63H111N11O12
Formula Weight: 1214.62
MOL File: 121584-18-7.mol

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Valspodar Property

Melting point:: 143-145°C
Boiling point:: 1290.1±65.0 °C(Predicted)
alpha: D20 -255.1° (c = 0.5 in CHCl3)
Density: 1.015±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.45±0.70(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0572
Product name: Valspodar
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $184
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML0572
Product name: Valspodar
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $723
Updated: 2023/01/07

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 500μg
Price: $25
Updated: 2023/01/06

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 1mg
Price: $48
Updated: 2023/01/06

Cayman Chemical

Product number: 20391
Product name: PSC 833
Purity: ≥95%
Packaging: 5 mg
Price: $163
Updated: 2023/01/06

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Valspodar Chemical Properties,Usage,Production

Description

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [¹⁴C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

Chemical Properties

White Solid

Uses

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Uses

Antineoplastic adjunct (chemosensitizer).

brand name

Amdray (Novartis).

Biochem/physiol Actions

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Valspodar Preparation Products And Raw materials

Raw materials

Preparation Products

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Valspodar Suppliers

Canada 1 China 88 India 3 Japan 1 United Kingdom 4 United States 16 Global 113

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-3101919
Fax: 708-557-7486
Email: sales@invivochem.net
Country: United States
ProdList: 6395
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

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View Lastest Price from Valspodar manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Valspodar 121584-18-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Valspodar 121584-18-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

121584-18-7, ValspodarRelated Search:

Vadadustat Vanoxerine dihydrochloride Nintedanib [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Vardenafil hydrochloride trihydrate Vandetanib PF 543 ALK5 inhibitor II PF-543 (Citrate) CHIR-99021

Valspodar

3'-Keto-bmt(1)-Val(2)-cyclosporin a

Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-

Psc 833

Sdz psc 833

Sdz-psc-833

Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]

6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA

Valspodar(PSC-833,AMdray)

6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D

6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A

AMdray

Valpodar

PSC833(Valspodar)

Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine-

Valspodar (PSC-833)

[3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin

6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D

PSC833 - Specific MDR1/P-gp Inhibitor

Valspodar, >=98%

CS-51

PSC 833; PSC-833; PSC833

121584-18-7

Intermediates & Fine Chemicals

Peptides

Pharmaceuticals