Carbodine
- Product Name
- Carbodine
- CAS No.
- 71184-20-8
- Chemical Name
- Carbodine
- Synonyms
- C-Cyd;Carbodine;Carbodine (Carbocyclic cytidine);4-Amino-1-[(1R)-2α,3α-dihydroxy-4β-(hydroxymethyl)cyclopentan-1β-yl]-2(1H)-pyrimidinone;4-Amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-2(1H)-pyrimidinone;2(1H)-Pyrimidinone, 4-amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-
- CBNumber
- CB71178217
- Molecular Formula
- C10H15N3O4
- Formula Weight
- 241.24
- MOL File
- 71184-20-8.mol
Carbodine Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Carbodine Chemical Properties,Usage,Production
Uses
Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent active against DNA viruses, (+)RNA viruses, (-)RNA viruses, paramyxo, rhabdo and (+/-)RNA viruses, targets CTP synthetase that converts UTP to CTP. Carbodine (Carbocyclic cytidine) possesses significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 in vitro[1][2].
References
[1] De Clercq E, et al. Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine. Biochem Pharmacol. 1990 Jan 15;39(2):319-25. DOI:10.1016/0006-2952(90)90031-f
[2] Shannon WM, et al. Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses. Antimicrob Agents Chemother. 1981 Dec;20(6):769-76. DOI:10.1128/AAC.20.6.769