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Dexelvucitabine

Product Name
Dexelvucitabine
CAS No.
134379-77-4
Chemical Name
Dexelvucitabine
Synonyms
RVT;YZ 817;D-D-4FC;DPC-817;Reverset;RA 131423;INCB 8721;beta-D-D-4FC;Dexelvucitabine;Dexelvucitabine, 10 mM in DMSO
CBNumber
CB71178464
Molecular Formula
C9H10FN3O3
Formula Weight
227.19
MOL File
134379-77-4.mol
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Dexelvucitabine Property

Boiling point:
394.9±52.0 °C(Predicted)
Density 
1.66±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
form 
Solid
pka
14.28±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
NF58422
Product name
5-Fluoro-1-(2',3'-dideoxy-2',3'-didehydro-b-D-arabinofuranosyl)-cytosine
Packaging
25mg
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
NF58422
Product name
5-Fluoro-1-(2',3'-dideoxy-2',3'-didehydro-b-D-arabinofuranosyl)-cytosine
Packaging
50mg
Price
$363
Updated
2021/12/16
Biosynth Carbosynth
Product number
NF58422
Product name
5-Fluoro-1-(2',3'-dideoxy-2',3'-didehydro-b-D-arabinofuranosyl)-cytosine
Packaging
100mg
Price
$580
Updated
2021/12/16
Biosynth Carbosynth
Product number
NF58422
Product name
5-Fluoro-1-(2',3'-dideoxy-2',3'-didehydro-b-D-arabinofuranosyl)-cytosine
Packaging
250mg
Price
$880
Updated
2021/12/16
AK Scientific
Product number
3713CA
Product name
Dexelvucitabine
Packaging
250mg
Price
$1238
Updated
2021/12/16
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Dexelvucitabine Chemical Properties,Usage,Production

Uses

Treatment of HIV-1 and HIV-2 infection.

Uses

Dexelvucitabine is a nucleoside reverse transcriptase inhibitor (NRTI) which had the potential to inhibit HIV-1 replication. The drug was discontinued due to evidence that it causes damage to the pancreas.

brand name

Reverset (Incyte).

in vivo

Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t1/2α?and?t1/2β, respectively) of 0.7 and 3.6 h in monkeys, respectively. The Cmax ranges from 21.1 to 47.5 μM[2].
Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively)?in woodchucks[2].

IC 50

HIV-1

Dexelvucitabine Preparation Products And Raw materials

Raw materials

Preparation Products

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Dexelvucitabine Suppliers

China 22 South Korea 1 United Kingdom 1 United States 5 Global 29
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58

134379-77-4, DexelvucitabineRelated Search:

5-Fluorocytidine Dexelvucitabine 2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-FLUORO-BETA-D-CYTIDINE, [6-3H]-

  • Dexelvucitabine
  • 2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine
  • 4-AMINO-5-FLUORO-1-[(2R,5S)-5-(HYDROXYMETHYL)-2,5-DIHYDROFURAN-2-YL]PYRIMIDIN-2(1H)-ONE
  • Cytidine,2',3'-didehydro-2',3'-dideoxy-5-fluoro-
  • INCB 8721
  • RA 131423
  • Reverset
  • YZ 817
  • 5-Fluoro-1-(2',3'-dideoxy-2',3'-didehydro-b-D-arabinofuranosyl)-cytosine
  • 2’,3’-Dideoxy-2’,3’-didehydro-5-fluoro-cytidine, FddddC, Dexelvucitabine (DFC), Reverset
  • beta-D-D-4FC
  • D-D-4FC
  • DPC-817
  • RVT
  • 5-Fluoro-1-(2’,3’-dideoxy-2’,3’-didehydro-β-D-arabinofuranosyl)-cytosine (Dexelvucitabine)
  • Inhibitor,thymidine,Human immunodeficiency virus,d-d4FC,cytidine,M184V mutation,antiretroviral,inhibit,Reverset,2′-deoxycytidine,viral polymerase,Dexelvucitabine,HIV,resistant viruse,nucleoside reverse transcriptase,HIV-1,Reverse Transcriptase
  • 2',3'-didehydro-2',3'-dideoxy-5-fluoroCytidine
  • Dexelvucitabine, 10 mM in DMSO
  • 134379-77-4