5-Phenylthiophene-2-carboxylic acid

Uses

Product Name: 5-Phenylthiophene-2-carboxylic acid
CAS No.: 19163-24-7
Chemical Name: 5-Phenylthiophene-2-carboxylic acid
Synonyms: AKOS B029964;AKOS BAR-0576;BUTTPARK 98\04-16;RARECHEM AL BE 0489;5-Phenyl-2-thenoic Acid;2-Carboxy-5-phenylthiophene;5-phenyl-2-furancarbothioic S-acid;5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID;5-PHENYL-2-THIOPHENECARBOXYLIC ACID;2-Thiophenecarboxylic acid, 5-phenyl-
CBNumber: CB7123393
Molecular Formula: C11H8O2S
Formula Weight: 204.24
MOL File: 19163-24-7.mol

More

Less

5-Phenylthiophene-2-carboxylic acid Property

Melting point:: 186-190°C
Boiling point:: 393.6±30.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: powder to crystal
pka: 3.52±0.10(Predicted)
color: White to Orange to Green
λmax: 310nm(EtOH)(lit.)
CAS DataBase Reference: 19163-24-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
HazardClass: IRRITANT
HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L498998
Product name: 5-PHENYL-2-THIOPHENECARBOXYLIC ACID
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $42.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: L498998
Product name: 5-PHENYL-2-THIOPHENECARBOXYLIC ACID
Purity: AldrichCPR
Packaging: 250MG
Price: $41.5
Updated: 2024/03/01

TCI Chemical

Product number: P2347
Product name: 5-Phenyl-2-thiophenecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 250mg
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: P2347
Product name: 5-Phenyl-2-thiophenecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $149
Updated: 2025/07/31

TRC

Product number: P320933
Product name: 5-Phenylthiophene-2-carboxylicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

More

Less

5-Phenylthiophene-2-carboxylic acid Chemical Properties,Usage,Production

Uses

Thiophene derivatives are widely used in the synthesis of pesticides, pharmaceuticals, chemical reagents, dyes, and polymer auxiliaries. 5-Phenylen-2-carboxylic acid has extensive applications in organic synthesis.

Definition

ChEBI: 5-Phenylthiophene-2-carboxylic acid is a thiophenecarboxylic acid.

Synthesis

14597-62-7

19163-24-7

GENERAL STEPS: To a mixed solution of methanol (5 mL) and tetrahydrofuran (5 mL) of 2-methoxycarbonyl-5-phenylthiophene (437 mg) was added 1 N aqueous sodium hydroxide (3 mL), and the reaction was stirred for 2 hours at room temperature. After completion of the reaction, 1 N hydrochloric acid (5 mL) was slowly added to the reaction mixture for acidification. The precipitated solid was collected by filtration and washed with a small amount of cold water and dried under vacuum to give 5-phenylthiophene-2-carboxylic acid (397 mg, 97.1% yield). The product was confirmed by NMR hydrogen spectrum (DMSO-d6, δ): 7.3-7.5 (3H, m), 7.58 (1H, d, J = 3.9 Hz), 7.6-7.8 (3H, m), 13.15 (1H, wide s). Electrospray mass spectrometry (ESI-MS) showed m/z: 203 ([M-H]-).

References

[1] Patent: US6770667, 2004, B1. Location in patent: Page column 11
[2] ChemMedChem, 2011, vol. 6, # 2, p. 362 - 377
[3] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5536 - 5548

5-Phenylthiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Iodobenzene Palladium (II) Acetate Silver nitrate 2-Thiophenecarboxaldehyde N,N-Dimethylformamide Potassium hydroxide Cesium carbonate Triphenylphosphine

Preparation Products

More

Less

5-Phenylthiophene-2-carboxylic acid Suppliers

Belgium 1 China 96 Europe 1 Germany 6 India 4 Japan 1 Russia 1 The Netherlands 1 Ukraine 2 United Kingdom 7 United States 18 Global 138

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

19163-24-7, 5-Phenylthiophene-2-carboxylic acidRelated Search:

Thifensulfuron methyl 3-Thiophenemalonic acid Tetrahydrothiophene Cephalothin sodium 2-Thiophenecarboxylic acid hydrazide Thifensulfuron EPA Dibenzothiophene 2-Thiophenecarboxylic acid POLYTHIOPHENE METHYL 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate 3-AMINO-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID ,3-AMINO-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester ETHYL 3-AMINO-5-(4-NITROPHENYL)THIOPHEN& METHYL 3-AMINO-5-(4-ISOBUTYLPHENYL)THIOPHENE-2-CARBOXYLATE METHYL 8-CHLORO-4H-BENZO[B]THIENO[2,3-D]THIINE-2-CARBOXYLATE

BUTTPARK 98\04-16

JR-6467, 5-Phenylthiophene-2-carboxylic acid, 97%

5-phenyl-2-furancarbothioic S-acid

AKOS B029964

AKOS BAR-0576

5-PHENYL-2-THIOPHENECARBOXYLIC ACID

5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID

RARECHEM AL BE 0489

2-Carboxy-5-phenylthiophene

2-Carboxy-5-phenylthiophene, 5-Phenyl-2-thenoic acid

5-Phenylthiophene-2-carboxylic acid, 95+%

2-Thiophenecarboxylic acid, 5-phenyl-

5-Phenyl-2-thenoic Acid

19163-24-7

API intermediates

Acids and Derivatives

Heterocycles