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girinimbine

Product Name
girinimbine
CAS No.
23095-44-5
Chemical Name
girinimbine
Synonyms
Girinimbin;girinimbine;Girinimbine, 10 mM in DMSO;3,3,5-Trimethyl-3,11-dihydropyrano[3,2-a]carbazole;3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole;Pyrano[3,2-a]carbazole, 3,11-dihydro-3,3,5-trimethyl-
CBNumber
CB71354004
Molecular Formula
C18H17NO
Formula Weight
263.33
MOL File
23095-44-5.mol
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girinimbine Property

Melting point:
176 °C
Boiling point:
450.0±34.0 °C(Predicted)
Density 
1.187±0.06 g/cm3(Predicted)
pka
17.31±0.40(Predicted)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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girinimbine Chemical Properties,Usage,Production

Uses

Girinimbine is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis and has antibacterial, anti-inflammatory, antioxidant and antitumor activities.

Definition

ChEBI: A natural product found in Clausena harmandiana.

in vivo

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2].
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2].

Animal Model:Male ICR mice (25-35 g) treated with carrageenan[2]
Dosage:10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:Orally gavage; once
Result:Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

girinimbine Preparation Products And Raw materials

Raw materials

Preparation Products

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girinimbine Suppliers

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23095-44-5, girinimbineRelated Search:


  • girinimbine
  • 3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole
  • Pyrano[3,2-a]carbazole, 3,11-dihydro-3,3,5-trimethyl-
  • Girinimbin
  • Girinimbine, 10 mM in DMSO
  • 3,3,5-Trimethyl-3,11-dihydropyrano[3,2-a]carbazole
  • 23095-44-5