(N-ME-PHE7)-NEUROKININ B

Product Name: (N-ME-PHE7)-NEUROKININ B
CAS No.: 110880-53-0
Chemical Name: (N-ME-PHE7)-NEUROKININ B
Synonyms: L-Methioninamide, L-α-aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-
CBNumber: CB71478502
Molecular Formula: C60H81N13O14S2
Formula Weight: 1272.49
MOL File: 110880-53-0.mol

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(N-ME-PHE7)-NEUROKININ B Property

form: Solid
color: White to off-white
Sequence: Asp-Met-His-Asp-Phe-Phe-{MePhe}-Gly-Leu-Met-NH2

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Hazard and Precautionary Statements (GHS)

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(N-ME-PHE7)-NEUROKININ B Chemical Properties,Usage,Production

Uses

[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R)[1].

IC 50

NK3: 3 nM (IC₅₀)

References

[1] Misu R, et, al. Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists. Bioorg Med Chem. 2013 Apr 15;21(8):2413-2417. DOI:10.1016/j.bmc.2013.01.036

(N-ME-PHE7)-NEUROKININ B Preparation Products And Raw materials

Raw materials

Preparation Products

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110880-53-0, (N-ME-PHE7)-NEUROKININ BRelated Search:

L-Methioninamide, L-α-aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-

110880-53-0

C60H81N13O14S2