5-FLUOROINDOLE-3-CARBOXYLIC ACID
Application- Product Name
- 5-FLUOROINDOLE-3-CARBOXYLIC ACID
- CAS No.
- 23077-43-2
- Chemical Name
- 5-FLUOROINDOLE-3-CARBOXYLIC ACID
- Synonyms
- 5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID;RARECHEM AL BE 0942;5-fluoro-indol-3-carboxylic acid;5-FLUOROINDOLE-3-CARBOXYLIC ACID;5-Fluoro-1H-indol-3-carboxylic acid;1H-INDOLE-3-CARBOXYLIC ACID,5-FLUORO
- CBNumber
- CB7165041
- Molecular Formula
- C9H6FNO2
- Formula Weight
- 179.15
- MOL File
- 23077-43-2.mol
5-FLUOROINDOLE-3-CARBOXYLIC ACID Property
- Melting point:
- 234-236 °C (decomp)
- Boiling point:
- 422.2±25.0 °C(Predicted)
- Density
- 1.510±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.76±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F600548
- Product name
- 5-Fluoro-1H-indole-3-carboxylicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC201206
- Product name
- 5-Fluoro-1H-indole-3-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $106
- Updated
- 2021/12/16
- Product number
- PC201206
- Product name
- 5-Fluoro-1H-indole-3-carboxylicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- W4691
- Product name
- 5-Fluoro-1H-indole-3-carboxylicacid
- Packaging
- 5g
- Price
- $517
- Updated
- 2021/12/16
- Product number
- PC201206
- Product name
- 5-Fluoro-1H-indole-3-carboxylicacid
- Purity
- 97%
- Packaging
- 10g
- Price
- $566
- Updated
- 2021/12/16
5-FLUOROINDOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Application
5-Fluoroindole-3-carboxylic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.
Synthesis
1260793-83-6
23077-43-2
General procedure for the synthesis of 5-fluoro-1H-indole-3-carboxylic acid from 2,2,2-trifluoro-1-(5-fluoro-1H-indol-3-yl)ethanone: 2,2,2-trifluoro-1-[5-fluoro-1-(pyrimidin-2-yl)-1H-indol-3-yl]ethan-1-one (1.6 g) and 5 N aqueous sodium hydroxide were added to the reaction flask. The reaction mixture was stirred under heated reflux conditions for 1.5 hours. After completion of the reaction, the reaction solution was cooled to room temperature and extracted by adding water and ethyl acetate. After separating the organic and aqueous layers, the aqueous layer was made acidic with concentrated hydrochloric acid. The acidic aqueous layer was again extracted with ethyl acetate, the organic layers were combined and washed with saturated saline. The organic layer was dried with anhydrous sodium sulfate and the solvent was removed by distillation under reduced pressure to give 785 mg of 5-fluoro-1H-indole-3-carboxylic acid (88% yield).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 17, p. 7293 - 7316
[2] Patent: EP2548864, 2013, A1. Location in patent: Paragraph 0178; 0179
[3] Patent: WO2013/14102, 2013, A1. Location in patent: Page/Page column 26; 32; 33
[4] Patent: JP2017/171619, 2017, A. Location in patent: Paragraph 0168; 0170
5-FLUOROINDOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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