Vinflunine Ditartrate
- Product Name
- Vinflunine Ditartrate
- CAS No.
- 194468-36-5
- Chemical Name
- Vinflunine Ditartrate
- Synonyms
- Javlor;F 12158;BMS 710485;Ditartrate;Vinflunine Ditartrate;Vinflunine ditartrate (BMS 710485);20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate;(2β,3β,4β,5α,12β,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(Methoxycarbonyl)-2,6-Methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-Methoxy-1-MethylaspidosperMidine-3-carboxylic Acid Methyl Ester (2R,3R)-2,3-Dihydroxybutanedioate
- CBNumber
- CB71873477
- Molecular Formula
- C49H59F2N4O14
- Formula Weight
- 966.0079664
- MOL File
- 194468-36-5.mol
Vinflunine Ditartrate Property
- Melting point:
- 244-246°C (dec)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Light Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- V314500
- Product name
- VinflunineDitartrate
- Packaging
- 100mg
- Price
- $1485
- Updated
- 2021/12/16
- Product number
- API0009962
- Product name
- VINFLUNINE DITARTRATE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1963.5
- Updated
- 2021/12/16
- Product number
- 53418
- Product name
- VinflunineDitartrate
- Packaging
- 50mg
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- FV28698
- Product name
- Vinflunine ditartrate
- Packaging
- 1mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- FV28698
- Product name
- Vinflunine ditartrate
- Packaging
- 2mg
- Price
- $196
- Updated
- 2021/12/16
Vinflunine Ditartrate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Vinflunine is a semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity. Vinflunine is a derivative of Vinorelbine. Vinflunine is used as an antineoplastic.
Uses
Vinflunine Ditartrate can be used as Semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity; derivative of Vinorelbine.
Clinical Use
Vinflunine ditartrate is a second generation difluorinated analog of the naturally-occuring substance vinorelbine and it is approved for the treatment of non-small cell lung cancer, metastatic breast cancer and ovarian cancer. Vinflunine, a tubulin polymerization inhibitor, belongs to the vinca alkaloid class of anti-cancer agents. Introduction of the difluoro group of vinflunine dramatically improved antitumor activity of the parent vinorelbine structure. Vinflunine was discovered by Pierre Fabre Laboratories and in 2004 was licensed to Bristol-Myers Squibb for development and commercialization. In 2007, the rights to venflunine were returned to Pierre Fabre which completed its development.
Synthesis
Vinflunine can be prepared directly from vinorelbine (155) through the use of superacid chemistry. Reaction of 155 with antimony pentaflouride in hydrofluoric acid and Nbromosuccinimide followed by treatment with two equivalents of tartaric acid produced vinflunine ditartrate (XV) in 25% yield. An alternative synthesis of vinflunine was realized through reaction of vinblastine or 3?ˉ,4?ˉ-dihydrovinblastine (156) with antimony pentaflouride and hydrofluoric acid in chloroform to give the difluoro alkaloid 157 in 40% yield Ring contraction was effected by reaction with trifluoroacetic acid and N-bromosuccinimide followed by aqueous sodium bicarbonate and silver tetrafluoroborate to give vinflunine in 88% yield. Vinflunine ditartrate (XV) was prepared by treating a solution of vinflunine in toluene with two equivalents of tartaric acid.
Vinflunine Ditartrate Preparation Products And Raw materials
Raw materials
Preparation Products
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