ChemicalBook > CAS DataBase List > 1-bromo-2,5-dimethyl-4-nitrobenzene

1-bromo-2,5-dimethyl-4-nitrobenzene

Product Name
1-bromo-2,5-dimethyl-4-nitrobenzene
CAS No.
15540-81-5
Chemical Name
1-bromo-2,5-dimethyl-4-nitrobenzene
Synonyms
4-Bromo-2,5-dimethylnitrobenzene;1-bromo-2,5-dimethyl-4-nitrobenzene;Benzene, 1-bromo-2,5-dimethyl-4-nitro-;1-Bromo-2,5-dimethyl-4-nitrobenzene 98%;1-Bromo-2,5-dimethyl-4-nitro-benzene（2-Bromo-5-nitro-p-xylene）
CBNumber
CB71882877
Molecular Formula
C8H8BrNO2
Formula Weight
230.06
MOL File
15540-81-5.mol
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1-bromo-2,5-dimethyl-4-nitrobenzene Property

Melting point:
70 °C
Boiling point:
288.8±35.0 °C(Predicted)
Density 
1.533±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Appearance
light green to green Solid
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Safety

HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B691663
Product name
1-Bromo-2,5-dimethyl-4-nitro-benzene
Packaging
100mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
4754-9-47
Product name
1-Bromo-2,5-dimethyl-4-nitrobenzene
Packaging
1g
Price
$245
Updated
2021/12/16
AK Scientific
Product number
9765AH
Product name
1-Bromo-2,5-dimethyl-4-nitrobenzene
Packaging
250mg
Price
$136
Updated
2021/12/16
SynQuest Laboratories
Product number
4754-9-47
Product name
1-Bromo-2,5-dimethyl-4-nitrobenzene
Packaging
250mg
Price
$100
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0069328
Product name
1-BROMO-2,5-DIMETHYL-4-NITRO-BENZENE
Purity
97.00%
Packaging
5MG
Price
$502.99
Updated
2021/12/16
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1-bromo-2,5-dimethyl-4-nitrobenzene Chemical Properties,Usage,Production

Synthesis

3460-29-5

15540-81-5

General Steps: Part A-Preparation of copper (I) bromide solution: dissolve copper (I) bromide (72.5 g, 505 mmol) in 37% hydrochloric acid (150 mL) and heat to 80°C until a clarified solution is formed. Part B-Diazotization and Sandmeyer bromination: to a concentrated hydrochloric acid solution (150 mL) of 2,5-dimethyl-4-nitroaniline (21 g, 126 mmol), a mixture of saturated sodium nitrite solution (1.7 g, 253 mmol) and water (20 mL) was added slowly and dropwise at 0°C with continuous stirring for 30 min. Subsequently, copper (I) bromide solution prepared in part A was added slowly and dropwise at the same temperature. After addition, the reaction mixture was warmed up to 80 °C and maintained for 1 hour. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the target product 1-bromo-2,5-dimethyl-4-nitrobenzene (22 g, 76% yield) was purified by column chromatography (eluent: hexane/ethyl acetate, 8:2).

References

[1] Patent: WO2018/211442, 2018, A1. Location in patent: Page/Page column 71-72
[2] Recueil des Travaux Chimiques des Pays-Bas, 1956, vol. 75, p. 1137,1138, 1149

1-bromo-2,5-dimethyl-4-nitrobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-bromo-2,5-dimethyl-4-nitrobenzene Suppliers

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15540-81-5, 1-bromo-2,5-dimethyl-4-nitrobenzeneRelated Search:

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