ChemicalBook > CAS DataBase List > 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Product Name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
CAS No.
981-34-0
Chemical Name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Synonyms
DB11;(9β,11β,16β)-;Einecs 213-563-4;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid;16-BETA METHYL EPOXIDE;DB11(16B-Methyl Epoide);DB11(16β-Methyl Epoide)
CBNumber
CB72129663
Molecular Formula
C22H28O5
Formula Weight
372.45
MOL File
981-34-0.mol
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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Property

Melting point:
210-220 ºC
Boiling point:
564.9±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
vapor pressure 
0-357.304Pa at 25℃
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
form 
Solid
pka
12.56±0.70(Predicted)
color 
White to Light Beige
InChIKey
GBDXNHBVYAMODG-OBDZOPJXNA-N
SMILES
C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E589175
Product name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging
250mg
Price
$95
Updated
2021/12/16
TRC
Product number
E589175
Product name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging
2g
Price
$160
Updated
2021/12/16
Usbiological
Product number
262572
Product name
Betamethasone 9,11-epoxide
Packaging
1g
Price
$360
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18569
Product name
Betamethasone 9,11-epoxide
Packaging
50g
Price
$450
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18569
Product name
Betamethasone 9,11-epoxide
Packaging
25g
Price
$250
Updated
2021/12/16
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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

Description

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemical Properties

Off-White Solid

Uses

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.

Preparation

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Suppliers

Nanjing Shizhou Biotechnology Co., Ltd
Tel
025-85563444 15850508050
Fax
18013869214
Email
rose.shi@synzest.com
Country
China
ProdList
292
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
027-81302411 15377658509
Email
zs@dkybpc.com
Country
China
ProdList
2057
Advantage
58
Hubei Aiputi Bioengineering Co., Ltd.
Tel
17762444226
Email
d17762444226@163.com
Country
China
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2402
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58
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
Email
shchemsky@sina.com
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China
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50
XiaoGan ShenYuan ChemPharm co,ltd
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0712-0712-2580635 15527768850
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1791901229@qq.com
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China
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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China
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T&W GROUP
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021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
4000505016; 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5000
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50
Clearsynth Labs Limited
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+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9685
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View Lastest Price from 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione manufacturers

Nantong Guangyuan Chemicl Co,Ltd
Product
16-beta Methyl Epoxide 981-34-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-03
LY Global chemicals co.,ltd .
Product
9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione 981-34-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98.0%min
Supply Ability
100kg
Release date
2023-03-11
Hebei Zhanyao Biotechnology Co. Ltd
Product
Betamethasone 9,11-Epoxide 981-34-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-08

981-34-0, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Related Search:


  • 16-BETA METHYL EPOXIDE
  • 9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
  • DB11
  • (9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • Einecs 213-563-4
  • Betamethasone 9,11-Epoxide
  • (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione
  • (9β,11β,16β)-
  • 9beta,11beta-Epoxy-1
  • DB11(16B-Methyl Epoide)
  • DB11(16β-Methyl Epoide)
  • (4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
  • Betamethasone epoxide
  • (4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
  • Pregna-1,4-diene-3,20-dione,9
  • 17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione
  • Beclomethasone EP Impurity R
  • Betamethasone Impurity 5(Betamethasone EP Impurity E)
  • Beclometasone Dipropionate?EP Impurity R
  • 16-beta Methyl Epoxid
  • 9,11beta-Epoxy-17,21-dihydroxy-16be
  • 9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]
  • Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-
  • Beclomethasone Impurity 6
  • Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
  • Beclomethasone propionate EP impurity R
  • Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)
  • 9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...
  • DB11(16β-Methyl Epoxide)
  • 11beta-Epoxy-17alpha
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • 9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
  • Beclomethasone dipropionate EP Impurity R
  • 9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione
  • Beclometasone Dipropionate Impurity R
  • Beclometasone Propionate EP Impurity R
  • Betamethasone Impurity E
  • Beclometasone Propionate EP Impurity R(Betamethasone EP Impurity E)
  • Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)
  • Betamethasone epoxy hydrolysate
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione
  • 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met
  • 93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11)
  • Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 981-34-0
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids
  • 981-34-0