9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Product Name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
CAS No.: 981-34-0
Chemical Name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Synonyms: DB11;(9β,11β,16β)-;Einecs 213-563-4;16β Methyl Epoxide;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid;16-BETA METHYL EPOXIDE;DB11(16β-Methyl Epoide)
CBNumber: CB72129663
Molecular Formula: C22H28O5
Formula Weight: 372.45
MOL File: 981-34-0.mol

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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Property

Melting point:: 210-220 ºC
Boiling point:: 564.9±50.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
vapor pressure: 0-357.304Pa at 25℃
storage temp.: Refrigerator
solubility: Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
form: Solid
pka: 12.56±0.70(Predicted)
color: White to Light Beige
InChIKey: GBDXNHBVYAMODG-OBDZOPJXNA-N
SMILES: C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E589175
Product name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging: 250mg
Price: $95
Updated: 2021/12/16

TRC

Product number: E589175
Product name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging: 2g
Price: $160
Updated: 2021/12/16

Usbiological

Product number: 262572
Product name: Betamethasone 9,11-epoxide
Packaging: 1g
Price: $360
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18569
Product name: Betamethasone 9,11-epoxide
Packaging: 2g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18569
Product name: Betamethasone 9,11-epoxide
Packaging: 5G
Price: $80
Updated: 2021/12/16

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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

Description

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemical Properties

Off-White Solid

Uses

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.

Preparation

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.

Toxics Screening Level

The initial threshold screening level (ITSL) for betamethasone 11 is 17 μg/m3 based on an annual averaging time.

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Suppliers

Canada 2 China 229 India 12 United Kingdom 1 United States 8 Global 252

Nanjing Shizhou Biotechnology Co., Ltd

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S.Z. PhyStandard Bio-Tech. Co., Ltd.

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Clearsynth Labs Limited

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View Lastest Price from 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione manufacturers

LY Global chemicals co.,ltd .

Product: 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione 981-34-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-11

Hebei Zhanyao Biotechnology Co. Ltd

Product: Betamethasone 9,11-Epoxide 981-34-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-08

Hebei Zhanyao Biotechnology Co. Ltd

Product: Betamethasone 9,11-Epoxide 981-34-0
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-28

981-34-0, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Related Search:

16-beta Methyl Epoxide ETHYLENE OXIDE Betamethasone 17-valerate Propylene glycol Estradiol Betamethasone 21-phosphate disodium Phenolic epoxy resin Basic Violet 1 Polyethylene Glycol Betamethasone 21-acetate Methylparaben Kresoxim-methyl Acetonitrile BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Methyl acrylate Betamethasone 4,4'-Diphenylmethane diisocyanate Methylene Blue

16-BETA METHYL EPOXIDE

9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione

DB11

(9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Einecs 213-563-4

Betamethasone 9,11-Epoxide

(9β,11β,16β)-

9beta,11beta-Epoxy-1

DB11(16B-Methyl Epoide)

DB11(16β-Methyl Epoide)

(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one

Betamethasone epoxide

(4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one

Pregna-1,4-diene-3,20-dione,9

17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione

Beclomethasone EP Impurity R

Betamethasone Impurity 5（Betamethasone EP Impurity E）

Beclometasone Dipropionate?EP Impurity R

16-beta Methyl Epoxid

9,11beta-Epoxy-17,21-dihydroxy-16be

9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]

Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-

Beclomethasone Impurity 6

Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione

Beclomethasone propionate EP impurity R

Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)

9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...

DB11(16β-Methyl Epoxide)

11beta-Epoxy-17alpha

9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione

Beclomethasone dipropionate EP Impurity R

9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione

Beclometasone Dipropionate Impurity R

Beclometasone Propionate EP Impurity R

Betamethasone Impurity E

Beclometasone Propionate EP Impurity R（Betamethasone EP Impurity E）

Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)

Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)

Betamethasone epoxy hydrolysate

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione

9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met

93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11)

(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

Betamethasone epoxide hydrolase

Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)

Beclometasone Impurity R

9,11beta-Epoxy-17,21-dihydroxy-16beta-methyl-9beta-pregna-1,4-diene-3,20-dione

Betamethasone Epoxide Hydrolyzate

Beclomethasone Propionate intermediate

DB Xl - 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione

16β Methyl Epoxide

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Betamethasone 9,11-Epoxide（DB11）

981-34-0

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals