4-Hydroxyphenyloxoacetic acid methyl ester

Product Name: 4-Hydroxyphenyloxoacetic acid methyl ester
CAS No.: 38250-16-7
Chemical Name: 4-Hydroxyphenyloxoacetic acid methyl ester
Synonyms: Methyl 4-hydroxy-α-oxobenzeneacetate;Methyl 2-(4-hydroxyphenyl)-2-oxoacetate;4-Hydroxyphenyloxoacetic acid methyl ester;4-Hydroxy-α-oxobenzeneacetic acid methyl ester;Benzeneacetic acid, 4-hydroxy-α-oxo-, methyl ester
CBNumber: CB72236664
Molecular Formula: C9H8O4
Formula Weight: 180.16
MOL File: 38250-16-7.mol

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4-Hydroxyphenyloxoacetic acid methyl ester Property

storage temp.: Inert atmosphere,Room Temperature
Appearance: White to off-white Solid
EPA Substance Registry System: Benzeneacetic acid, 4-hydroxy-.alpha.-oxo-, methyl ester (38250-16-7)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 5907AQ
Product name: methyl2-(4-hydroxyphenyl)-2-oxoacetate
Packaging: 1g
Price: $190.4
Updated: 2021/12/16

Acrotein

Product number: AS01306
Product name: Methyl2-(4-hydroxyphenyl)-2-oxoacetate
Purity: 97%
Packaging: 0.5g
Price: $220
Updated: 2021/12/16

Acrotein

Product number: AS01306
Product name: Methyl2-(4-hydroxyphenyl)-2-oxoacetate
Purity: 97%
Packaging: 1g
Price: $330
Updated: 2021/12/16

Crysdot

Product number: CD12076887
Product name: Methyl2-(4-hydroxyphenyl)-2-oxoacetate
Purity: 95+%
Packaging: 5g
Price: $339
Updated: 2021/12/16

Alichem

Product number: 38250167
Product name: Methyl2-(4-hydroxyphenyl)-2-oxoacetate
Packaging: 1g
Price: $488.22
Updated: 2021/12/16

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4-Hydroxyphenyloxoacetic acid methyl ester Chemical Properties,Usage,Production

Synthesis

37763-23-8

38250-16-7

Step 1: (R)-2-Amino-2-(4-hydroxyphenyl)acetic acid (D-4-hydroxyphenylglycine, 10.0 g, 60.1 mmol) was dissolved in methanol (200 mL) and thionyl chloride (8 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 10 hours. After completion of the reaction, the solvent was removed by vacuum concentration and the residue was washed twice with ether to afford methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 13.0 g, 60.0 mmol, 100% yield) as a white solid.1H NMR (300 MHz, DMSO-d6) δ 3.68 (s, 3H) 5.07 (s, 1H), 6.85 (d, J=8.5Hz, 2H), 7.29 (d, J=8.6Hz, 2H), 9.03 (s, 3H), 10.02 (s, 1H). Step 2: Methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 0.302 g, 1.39 mmol) was dissolved in freshly prepared glyoxalic acid (1.27 g, 13.8 mmol) and copper(II) sulfate pentahydrate (0.35 g, 1.40 mmol) in 2.5 M pyridine buffer and 0.5 M acetic acid in an aqueous solution. The reaction mixture was stirred at room temperature for 10 hours. Upon completion of the reaction, it was extracted with dichloromethane (10 mL x 3), the organic layers were combined, washed with 0.5 M HCl (20 mL x 3), dried, filtered and concentrated in vacuum. The residue was purified by flash column (silica gel, chloroform elution) to afford methyl 2-(4-hydroxyphenyl)-2-oxoacetate (0.109 g, 6.06 mmol, 44% yield) as a clear oil.1H NMR (300 MHz, CDCl3) δ 3.99 (s, 3H), 5.41 (br s, 1H), 6.95 (d, J=8.8 Hz, 2H), 8.00 (d, J=8.8Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 18, p. 3946 - 3952
[2] Patent: WO2013/33093, 2013, A1. Location in patent: Page/Page column 137; 138

4-Hydroxyphenyloxoacetic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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38250-16-7, 4-Hydroxyphenyloxoacetic acid methyl esterRelated Search:

Methyl 2-(4-hydroxyphenyl)-2-oxoacetate

4-Hydroxyphenyloxoacetic acid methyl ester

4-Hydroxy-α-oxobenzeneacetic acid methyl ester

Benzeneacetic acid, 4-hydroxy-α-oxo-, methyl ester

Methyl 4-hydroxy-α-oxobenzeneacetate

38250-16-7