ChemicalBook > CAS DataBase List > GR 79236

GR 79236

Product Name
GR 79236
CAS No.
124555-18-6
Chemical Name
GR 79236
Synonyms
GR 79236;GR 79236X;GR79236,GR-79236;GR-79236X;GR79236;N-[(1S,2S)-2-HYDROXYCYCLOPENTYL]ADENOSINE;Adenosine, N-[(1S,2S)-2-hydroxycyclopentyl]-;N-[(1S, TRANS)-2-HYDROXYCYCLOPENTYL]ADENOSINE;GR 79236X,N-[(1S, trans)-2-Hydroxycyclopentyl]adenosine;(2R,3R,4S,5R)-2-[6-[[(1S,2S)-2-hydroxycyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CBNumber
CB7224122
Molecular Formula
C15H21N5O5
Formula Weight
351.36
MOL File
124555-18-6.mol
More
Less

GR 79236 Property

Boiling point:
728.3±70.0 °C(Predicted)
Density 
1.89±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: 12 mg/mL
form 
solid
pka
13.12±0.70(Predicted)
color 
white
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28430
Product name
GR79236
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
28430
Product name
GR79236
Packaging
25mg
Price
$573
Updated
2024/03/01
Cayman Chemical
Product number
28430
Product name
GR79236
Packaging
5mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
28430
Product name
GR79236
Packaging
10mg
Price
$283
Updated
2024/03/01
TRC
Product number
G779530
Product name
GR79236
Packaging
25mg
Price
$240
Updated
2021/12/16
More
Less

GR 79236 Chemical Properties,Usage,Production

Uses

GR 79236 is an Adenosine A1-R agonist.

Definition

ChEBI: (2R,3R,4S,5R)-2-[6-[[(1S,2S)-2-hydroxycyclopentyl]amino]-9-purinyl]-5-(hydroxymethyl)oxolane-3,4-diol is a purine nucleoside.

Biological Activity

Adenosine A 1 receptor agonist (K i = 3.1 nM). Anticonvulsive in mice following systemic administration in vivo .

in vitro

gr79236 is a highly potent and selective a1 receptor agonist which is originally developed for the treatment of type 2 diabetes mellitus, as a cardioprotective agent and also for peripheral arterial occlusive diseases. gr79236 inhibited catecholamine-induced lipolysis in adipocytes at low concentrations [1]

in vivo

gr79236 has a pronounced effect on nefa and tg levels in both acute and chronic animal models, thus establishing the potential of this approach for the treatment of t2d [1]. gr79236 also can inhibit neurogenic vasodilation in anaesthetized rats, inhibit electrical stimulation of superior saggital sinusinduced trigeminovascular nociceptive transmission and cgrp release in anaesthetized cats and inhibit trigeminal nociception in humans [2].

IC 50

3.1 nm (ki)

References

[1] kiesman wf, elzein e, zablocki j. a1 adenosine receptor antagonists, agonists, and allosteric enhancers. handb exp pharmacol. 2009;(193):25-58.
[2] arulmani u, heiligers jp, centurión d, garrelds im, villalón cm, saxena pr. lack of effect of the adenosine a1 receptor agonist, gr79236, on capsaicin-induced cgrp release in anaesthetized pigs. cephalalgia. 2005 nov;25(11):1082-90.
[3] sneyd jr, langton ja, allan lg, peacock je, rowbotham dj. multicentre evaluation of the adenosine agonist gr79236x in patients with dental pain after third molar extraction. br j anaesth. 2007 may;98(5):672-6. epub 2007 apr 7.

GR 79236 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

GR 79236 Suppliers

China 41 Germany 1 India 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 9 Global 55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

124555-18-6, GR 79236Related Search:

GR 79236 6-(BETA-HYDROXYETHYLAMINO)-PURINE N6-CYCLOPENTYLADENOSINE trans-(1R,2R)-2-Aminocyclopentanol hydrochloride

  • GR 79236
  • GR 79236X
  • GR 79236X,N-[(1S, trans)-2-Hydroxycyclopentyl]adenosine
  • N-[(1S, TRANS)-2-HYDROXYCYCLOPENTYL]ADENOSINE
  • N-[(1S,2S)-2-HYDROXYCYCLOPENTYL]ADENOSINE
  • (2R,3R,4S,5R)-2-[6-[[(1S,2S)-2-hydroxycyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
  • GR-79236X;GR79236
  • Adenosine, N-[(1S,2S)-2-hydroxycyclopentyl]-
  • GR79236,GR-79236
  • 124555-18-6
  • C15H21O5N5