AR-A014418
- Product Name
- AR-A014418
- Chemical Name
- AR-A014418
- Synonyms
- AR-A014418;GSK-3BETA INHIBITOR VIII;N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA
- CBNumber
- CB7226373
- Molecular Formula
- C12H12N4O4S
- Formula Weight
- 308.31
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- 3966
- Product name
- AR-A014418
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $810
- Updated
- 2021/12/16
AR-A014418 Chemical Properties,Usage,Production
Enzyme inhibitor
This ATP-competitive protein kinase inhibitor (FW = 308.31 g/mol; CAS 487021-52-3; Solubility: 62 mg/mL DMSO; <1 mg/mL H2O) selectively targets glycogen synthase kinase 3β (GSK3β),with IC50 = 104 nM; Ki = 38 nM. Attesting to its high specificity for GSK3, AR-A014418 does not significantly inhibit Cdk2 or Cdk5 (IC50 > 100 μM) or 26 other kinases. AR-A014418 inhibits phosphorylation of the microtubule-associated protein Tau at Ser-396 (i.e., the GSK3-specific site) in cells stably expressing human four-repeat Tau. AR-A014418 protects N2A neuroblastoma cells against cell death mediated by inhibition of the phosphatidylinositol 3-kinase/protein kinase B survival pathway. AR- A014418 inhibits neurodegeneration mediated by b-amyloid peptide in hippocampal slices. Treatment of neuroblastoma cell lines with AR- A014418 reduced the level of GSK-3α phosphorylation at Tyr-279 compared to GSK-3β phosphorylation at Tyr-216, and attenuated growth via the maintenance of apoptosis.. AR-A014418-dependent antinociceptive effects are induced by modulation of the glutamatergic system through metabotropic and ionotropic (NMDA) receptors and the inhibition of TNF-α and IL-1β cytokine signaling.
AR-A014418 Preparation Products And Raw materials
Raw materials
Preparation Products
AR-A014418 Suppliers
- Tel
- 15527250409
- Fax
- QQ：2692360204
- wenhaotian12@163.com
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 18601717983
- guojing@bioleaper.com
- Country
- China
- ProdList
- 5616
- Advantage
- 58