ChemicalBook > CAS DataBase List > 5-AMINO-3-BROMOBENZONITRILE

5-AMINO-3-BROMOBENZONITRILE

Product Name
5-AMINO-3-BROMOBENZONITRILE
CAS No.
49674-16-0
Chemical Name
5-AMINO-3-BROMOBENZONITRILE
Synonyms
3-Bromo-5-cyanoaniline;3-Amino-5-bromobenzonitrile;5-AMINO-3-BROMOBENZONITRILE;Benzonitrile, 3-amino-5-bromo-
CBNumber
CB72455984
Molecular Formula
C7H5BrN2
Formula Weight
197.03
MOL File
49674-16-0.mol
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5-AMINO-3-BROMOBENZONITRILE Property

Boiling point:
320.2±22.0 °C(Predicted)
Density 
1.68±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
1.72±0.10(Predicted)
form 
powder
color 
Off-white
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Safety

HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
A594155
Product name
3-Amino-5-bromobenzonitrile
Packaging
100mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
072870
Product name
5-Amino-3-bromobenzonitrile
Purity
95+%
Packaging
1g
Price
$59
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA64099
Product name
3-Amino-5-bromobenzonitrile
Packaging
500g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA64099
Product name
3-Amino-5-bromobenzonitrile
Packaging
1g
Price
$125
Updated
2021/12/16
Matrix Scientific
Product number
072870
Product name
5-Amino-3-bromobenzonitrile
Purity
95+%
Packaging
5g
Price
$179
Updated
2021/12/16
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5-AMINO-3-BROMOBENZONITRILE Chemical Properties,Usage,Production

Synthesis

49674-15-9

49674-16-0

General procedure for the synthesis of 5-amino-3-bromobenzonitrile from 3-bromo-5-nitrobenzonitrile: 3-bromo-5-nitrobenzonitrile (3 g, 13.2 mmol) was dissolved in methanol (100 mL) and cooled in an ice water bath. To this solution zinc powder (3.46 g, 52.9 mmol) and acetic acid (6.05 mL, 106 mmol) were added sequentially. Exothermic phenomenon was observed 1 minute after the start of the reaction. After the reaction was carried out for 2 hours, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated to give the crude product. The crude product was purified using silica gel chromatography with a hexane solution of 0 to 50% ethyl acetate as eluent. The eluate containing the target product was collected and concentrated by evaporation to give 5-amino-3-bromobenzonitrile (2.1 g, 81% yield). The product was analyzed by high performance liquid chromatography (HPLC): retention time (RT) = 0.80 min (Waters Acquity UPLC BEH C18 column, 1.7 μm, 2.0 × 50 mm, mobile phase acetonitrile/water/0.05% trifluoroacetic acid, gradient elution, detection wavelength = 254 nm); mass spectrum (ES): m/z = 196.9/ 198.9 (79Br/81Br)[M+H]+; 1H NMR (DMSO-d6) δ 7.06-7.09 (m, 1H), 7.04 (t, J=2.0Hz, 1H), 6.87 (dd, J=2.1,1.4Hz, 1H), 5.91 (s, 2H).

References

[1] Patent: WO2016/183114, 2016, A1. Location in patent: Page/Page column 61
[2] Patent: WO2009/42694, 2009, A1. Location in patent: Page/Page column 111
[3] Patent: WO2009/42694, 2009, A1. Location in patent: Page/Page column 71
[4] Patent: WO2012/93101, 2012, A1. Location in patent: Page/Page column 241-242

5-AMINO-3-BROMOBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-3-BROMOBENZONITRILE Suppliers

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View Lastest Price from 5-AMINO-3-BROMOBENZONITRILE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
5-Amino-3-bromobenzonitrile 49674-16-0
Price
US $5.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
5-Amino-3-bromobenzonitrile 49674-16-0
Price
US $5.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-11-26
Career Henan Chemical Co
Product
5-AMINO-3-BROMOBENZONITRILE 49674-16-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

49674-16-0, 5-AMINO-3-BROMOBENZONITRILERelated Search:

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  • 49674-16-0