ChemicalBook > CAS DataBase List > 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
- Product Name
- 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
- CAS No.
- 412960-54-4
- Chemical Name
- 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
- Synonyms
- Eeyarestatin 1;Eeyarestatin I;Eeyarestatin I - CAS 412960-54-4 - Calbiochem;Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1;3-(4-Chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazineyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea;3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide;1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
- CBNumber
- CB72518902
- Molecular Formula
- C27H25Cl2N7O7
- Formula Weight
- 630
- MOL File
- 412960-54-4.mol
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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Property
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL
- form
- Light yellow-orange solid
- pka
- 9.13±0.40(Predicted)
- color
- Yellow to orange
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- E1286
- Product name
- Eeyarestatin I
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $324
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 324521
- Product name
- Eeyarestatin I
- Packaging
- 25mg
- Price
- $251
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10012609
- Product name
- Eeyarestatin 1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10012609
- Product name
- Eeyarestatin 1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $105
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10012609
- Product name
- Eeyarestatin 1
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $201
- Updated
- 2024/03/01
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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Chemical Properties,Usage,Production
Uses
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation.
Biochem/physiol Actions
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.
storage
Store at +4°C
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Suppliers
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- Fax
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- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
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