O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
- Product Name
- O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
- CAS No.
- 189209-27-6
- Chemical Name
- O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
- Synonyms
- NH2-PEG5-NHBOC;BOC-NH-PEG5-NH2;NHBoc-PEG5-amine;PROTAC Linker 17;Boc-NH-PEG(4)-NH2;NH2-PEG5-C2-NH-Boc;BOC-N-AMIDO-PEG5-NH2;BOC-AMINO-PEG5-AMINE;Boc-N-amido-PEG5-Azide;Boc-N-amido-PEG5-Amine
- CBNumber
- CB72557907
- Molecular Formula
- C17H36N2O7
- Formula Weight
- 380.48
- MOL File
- 189209-27-6.mol
O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Property
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A608875
- Product name
- O-(2-Aminoethyl)-O’-[2-(Boc-amino)ethyl]tetraethyleneGlycol
- Packaging
- 50mg
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- 0323AP
- Product name
- BocNH-PEG5-CH2CH2NH2
- Packaging
- 5g
- Price
- $1396
- Updated
- 2021/12/16
- Product number
- PEG7890
- Product name
- Boc-NH-PEG(5)-NH2
- Packaging
- 5G
- Price
- $2160
- Updated
- 2021/12/16
- Product number
- FB73001
- Product name
- BocNH-PEG5-CH2CH2NH2
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 282409
- Product name
- Boc-NH-PEG5-CH2CH2NH2
- Packaging
- 5g
- Price
- $1200
- Updated
- 2021/12/16
O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Chemical Properties,Usage,Production
Description
t-Boc-N-Amido-PEG5-amine is a Boc protected PEG linker containing an free amino group and5 PEG units. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters. The Boc group can be deprotected under mild acidic conditions to free the amine.
Uses
As a polyethyleneglycol (PEG) derivative, O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol can be used in the preparation of novel biochip technology for detection of explosives-TNT. It is also used as a reagent in the synthesis of chemical inducer of dimeriza tions (CID) to identify the protein target of inhibitors of Toxoplasma gondii invasion.
Synthesis
911209-07-9
189209-27-6
General procedure for the synthesis of tert-butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate from (17-azido-3,6,9,12,15-pentaoxaheptadecyl)carbamate: Compound 6 (5-PEG-Boc-Amino azide, 2.90 g, 8.0 mmol) was dissolved in a Parr reaction flask in 100 ml of ethyl acetate and 0.25 g of 10% Pd/C catalyst was added. The reaction mixture was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was diluted with 200 ml of ethyl acetate and filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to remove the solvent to give 2.41 g of crude product. The crude product was purified by silica gel column chromatography, first eluting using a mixed solvent system of 1% NH4OH/15% MeOH/84% CH2Cl2, and then switching to a mixed solvent system of 1% NH4OH/25% MeOH/74% CH2Cl2, and the target fractions were collected to give 1.37 g of purified product. The purified product was dissolved in toluene and concentrated again under reduced pressure to give 1.21 g (40% yield) of the target compound 7.
IC 50
PEGs; Alkyl/ether
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 586 - 590
[2] Organic and Biomolecular Chemistry, 2009, vol. 7, # 15, p. 3049 - 3060
[3] Synlett, 2015, vol. 26, # 19, p. 2707 - 2713
[4] Patent: US7230101, 2007, B1. Location in patent: Page/Page column 60; 79
O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol manufacturers
- Product
- BocNH-PEG5-CH2CH2NH2 189209-27-6
- Price
- US $319.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2025-11-15
- Product
- tert-butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate 189209-27-6
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12
- Product
- NHBoc-PEG5-amine 189209-27-6
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-04-02