14,15-EE-5(Z)-E

Product Name: 14,15-EE-5(Z)-E
CAS No.: 519038-92-7
Chemical Name: 14,15-EE-5(Z)-E
Synonyms: 14,15-EE-5(Z)-E;KZTLOTWHEAHQAZ-VNULFWPXSA-N;14,15-Epoxy-5(Z)-Eicosaenoic Acid;14,15-EE-5(Z)-E(solution in ethanol);13-[(2(R),3S)-3-pentyloxiranyl]-5(Z)-tridecenoic acid;5-Tridecenoic acid, 13-[(2R,3S)-3-pentyl-2-oxiranyl]-, (5Z)-rel-
CBNumber: CB72589889
Molecular Formula: C20H36O3
Formula Weight: 324.5
MOL File: 519038-92-7.mol

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14,15-EE-5(Z)-E Property

Boiling point:: 452.4±18.0 °C(Predicted)
Density: 0.957±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.5 mg/ml
pka: 4.76±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10004946
Product name: 14,15-EE-5(Z)-E
Purity: ≥98%
Packaging: 25μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10004946
Product name: 14,15-EE-5(Z)-E
Purity: ≥98%
Packaging: 50μg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 10004946
Product name: 14,15-EE-5(Z)-E
Purity: ≥98%
Packaging: 100μg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 10004946
Product name: 14,15-EE-5(Z)-E
Purity: ≥98%
Packaging: 500μg
Price: $680
Updated: 2024/03/01

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14,15-EE-5(Z)-E Chemical Properties,Usage,Production

Description

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.

Uses

14,15-EE-5(Z)-E is a structural analogue of 14, 15-epoxide dicartrienoic acid (14,15-EET). 14,15-EE-5(Z)-E antagonizes the relaxation of vascular smooth muscle induced by EET[1].

References

[1] Gauthier KM, et al. 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. Hypertension. 2003 Oct;42(4):555-61. DOI:10.1161/01.HYP.0000091265.94045.C7

14,15-EE-5(Z)-E Preparation Products And Raw materials

Raw materials

Preparation Products

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14,15-EE-5(Z)-E Suppliers

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519038-92-7, 14,15-EE-5(Z)-ERelated Search:

14,15-EE-5(Z)-E

KZTLOTWHEAHQAZ-VNULFWPXSA-N

5-Tridecenoic acid, 13-[(2R,3S)-3-pentyl-2-oxiranyl]-, (5Z)-rel-

13-[(2(R),3S)-3-pentyloxiranyl]-5(Z)-tridecenoic acid

14,15-Epoxy-5(Z)-Eicosaenoic Acid

14,15-EE-5(Z)-E(solution in ethanol)

519038-92-7