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BIX01294 (hydrochloride hydrate)

Product Name
BIX01294 (hydrochloride hydrate)
CAS No.
1808255-64-2
Chemical Name
BIX01294 (hydrochloride hydrate)
Synonyms
BIX01294 (hydrochloride hydrate);BIX01294 (hydrochloride hydrate),BIX-01294 (hydrochloride hydrate);N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrate trihydrochloride;2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
CBNumber
CB72590339
Molecular Formula
C28H41ClN6O3
Formula Weight
545.13
MOL File
1808255-64-2.mol
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BIX01294 (hydrochloride hydrate) Property

storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/ml; Water: 10 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
1mg
Price
$30
Updated
2024/03/01
Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
5mg
Price
$113
Updated
2024/03/01
Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
50mg
Price
$558
Updated
2024/03/01
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BIX01294 (hydrochloride hydrate) Chemical Properties,Usage,Production

Description

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.1,2,3 BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM).4 It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases.4 BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.5

Uses

BIX-01294 hydrochloride hydrate is a histone-lysine methyltransferase (HMTase) inhibitor, which selective inhibits the G9aHMTase with IC50 of 1.7 μM, reduces histone-3 lysine (9) methylation (H3K9me), induces autophagy and apoptosis in human glioma cells[1][2].

IC 50

G9a: 1.7 μM (IC50); GLP: 38 μM (IC50)

References

1. Tachibana, M., Sugimoto, K., Nozaki, M., et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis Genes Dev. 16(14),1779-1791(2002).
2. Wagschal, A., Sutherland, H.G., Woodfine, K., et al. G9a histone methyltransferase contributes to imprinting in the mouse placenta Mol. Cell Biol. 28(3),1104-1113(2008).
3. Thomas, L.R., Miyashita, H., Cobb, R.M., et al. Functional analysis of histone methyltransferase G9a in B and T lymphocytes J. Immunol. 181(1),485-493(2008).
4. Kubicek, S., O'Sullivan, R.J., August, E.M., et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase Mol. Cell 25,473-481(2007).
5. Shi, Y., Desponts, C., Do, J.T., et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds Cell Stem Cell 3(5),568-574(2008).

BIX01294 (hydrochloride hydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX01294 (hydrochloride hydrate) Suppliers

China 27 United States 5 Global 32
BOC Sciences
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1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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12952
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BOC Sciences
Tel
16314854226
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info@bocsci.com
Country
United States
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9923
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
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32435
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Cayman Chemical Company
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cayman@caymanchem.com
Country
United States
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Creative Enzymes
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Email
info@creative-enzymes.com
Country
United States
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6057
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1808255-64-2, BIX01294 (hydrochloride hydrate)Related Search:


  • BIX01294 (hydrochloride hydrate)
  • BIX01294 (hydrochloride hydrate),BIX-01294 (hydrochloride hydrate)
  • 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
  • N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrate trihydrochloride
  • 1808255-64-2