8-BroMo-2-chloro-6-fluoro-quinazoline
- Product Name
- 8-BroMo-2-chloro-6-fluoro-quinazoline
- CAS No.
- 953039-63-9
- Chemical Name
- 8-BroMo-2-chloro-6-fluoro-quinazoline
- Synonyms
- 8-Bromo-2-chloro-6-fluoro-quizoline;8-BroMo-2-chloro-6-fluoro-quinazoline;Quinazoline, 8-bromo-2-chloro-6-fluoro-
- CBNumber
- CB72594302
- Molecular Formula
- C8H3BrClFN2
- Formula Weight
- 261.48
- MOL File
- 953039-63-9.mol
8-BroMo-2-chloro-6-fluoro-quinazoline Property
- Boiling point:
- 308.8±35.0 °C(Predicted)
- Density
- 1.836
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- pka
- -1.75±0.30(Predicted)
- Appearance
- White to light brown Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B685613
- Product name
- 8-Bromo-2-chloro-6-fluoroquinazoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B685613
- Product name
- 8-Bromo-2-chloro-6-fluoroquinazoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3H32-F-12
- Product name
- 8-Bromo-2-chloro-6-fluoroquinazoline
- Purity
- 98%
- Packaging
- 250mg
- Price
- $643
- Updated
- 2021/12/16
- Product number
- 6401AC
- Product name
- 8-Bromo-2-chloro-6-fluoroquinazoline
- Packaging
- 5g
- Price
- $1026
- Updated
- 2021/12/16
- Product number
- 091904
- Product name
- 8-Bromo-2-chloro-6-fluoroquinazoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1143
- Updated
- 2021/12/16
8-BroMo-2-chloro-6-fluoro-quinazoline Chemical Properties,Usage,Production
Synthesis
953039-62-8
953039-63-9
Step 5. Synthesis of 8-bromo-2-chloro-6-fluoroquinazoline: 0.5 M of 8-bromo-6-fluoroquinazolin-2(1H)-one was suspended in phosphorochloridic acid chloride and heated to 110 °C in an oil bath. During the reaction, the suspension transformed to a brown solution within 20 min. The reaction was completed after 1 h as monitored by LCMS. Subsequently, the excess phosphorus trichloride was removed by distillation under reduced pressure. The residue was carefully poured into ice water and the pH was adjusted with aqueous sodium bicarbonate to 7. The reaction mixture was extracted with ethyl acetate, the organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the target compound 8-bromo-2-chloro-6-fluoroquinazoline in 89% yield. The product was characterized by electrospray mass spectrometry (ES/MS) with m/z of 261/263 (MH+).
References
[1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 332
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0203; 0212
[3] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0510-0511
8-BroMo-2-chloro-6-fluoro-quinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
8-BroMo-2-chloro-6-fluoro-quinazoline Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 8-BroMo-2-chloro-6-fluoro-quinazoline manufacturers
- Product
- 8-Bromo-2-chloro-6-fluoroquinazoline 953039-63-9
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2019-12-30