tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate

Product Name: tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
CAS No.: 630121-86-7
Chemical Name: tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
Synonyms: 1-Boc-3-[[(trifluoromethyl)sulfonyl]oxy]-2,5-dihydropyrrole;tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate;TERT-BUTYL 3-(((TRIFLUOROMETHYL)SULFONYL)OXY)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE (CAS# 630121-86-7);1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-3-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
CBNumber: CB72665844
Molecular Formula: C10H14F3NO5S
Formula Weight: 317.28
MOL File: 630121-86-7.mol

More

Less

tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate Property

Boiling point:: 344.6±42.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
pka: -4.36±0.40(Predicted)
InChI: InChI=1S/C10H14F3NO5S/c1-9(2,3)18-8(15)14-5-4-7(6-14)19-20(16,17)10(11,12)13/h4H,5-6H2,1-3H3
InChIKey: FXWRRWKJFCPRBG-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC=C(OS(C(F)(F)F)(=O)=O)C1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 9561AB
Product name: tert-Butyl3-(((trifluoromethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
Packaging: 250mg
Price: $244
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0369913
Product name: TERT-BUTYL-3-(((TRIFLUOROMETHYL)SULFONYL)OXY)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 250MG
Price: $307.65
Updated: 2021/12/16

Chemenu

Product number: CM196672
Product name: tert-Butyl3-(((trifluoromethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $464
Updated: 2021/12/16

Crysdot

Product number: CD11084210
Product name: tert-Butyl3-(((trifluoromethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $491
Updated: 2021/12/16

Ambeed

Product number: A134983
Product name: tert-Butyl3-(((trifluoromethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
Purity: 98+%
Packaging: 1g
Price: $507
Updated: 2021/12/16

More

Less

tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate Chemical Properties,Usage,Production

Synthesis

145100-51-2

101385-93-7

630121-86-7

Part A: Synthesis of tert-butyl 3-(trifluoromethylsulfonyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate 1. 1-tert-butoxycarbonyl-3-pyrrolidinone (370 mg, 2.0 mmol) was dissolved in THF (15 ml) at -78 °C. 2. lithium bis(trimethylmethylsilyl)amide (1M solution in THF, 2.2 ml, 2.2 mmol) was added slowly and the reaction mixture was stirred for 1 h at this temperature. 3. A solution of 2-[N,n-bis(trifluoromethanesulfonyl)amino]-5-chloropyridine (864 mg, 2.2 mmol) in THF (20 ml) was added dropwise. 4. the reaction mixture was continued to be stirred for 0.5 h, followed by a slow warming up to room temperature over a period of 3 h. The reaction was carried out by stirring. 5. The reaction was quenched with saturated sodium bicarbonate solution. 6. The reaction mixture was diluted with ethyl acetate and washed sequentially with 15% potassium bisulfate solution, saturated sodium bicarbonate solution, 1N sodium hydroxide solution, water and brine. 7. The organic layers were combined, dried with magnesium sulfate and concentrated in vacuum. 8. purification by fast chromatography (silica gel, 10% ethyl acetate/hexane) afforded tert-butyl 3-(trifluoromethylsulfonyloxy)-2H-pyrrole-1(5H)-carboxylate as a colorless oil (214 mg, 34% yield).

References

[1] Patent: US2006/235037, 2006, A1. Location in patent: Page/Page column 60
[2] Patent: WO2010/51245, 2010, A1. Location in patent: Page/Page column 50
[3] Patent: WO2010/77624, 2010, A1. Location in patent: Page/Page column 48

tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate Suppliers

China 26 India 1 United States 2 Global 29

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 8840
Advantage: 58

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2150
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Rong Lin Medical Technology Co., Ltd.

Tel: 18602194589
Email: lincy-110@163.com
Country: China
ProdList: 863
Advantage: 58

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9119
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Wuxi Rejoys chemical Technology Co., Ltd.

Tel: 0510-86103381
Fax: 0510-86103381
Email: sales@rejoyschem.com
Country: CHINA
ProdList: 976
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15117
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1010
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

chemmole

Tel: 400-168-9330 15013243073
Email: 597760450@qq.com
Country: China
ProdList: 2942
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62220
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Zhengzhou Converging Chemical Co. LTD

Tel: 0371-53399770 18037166334
Email: 2853031800@qq.com
Country: China
ProdList: 5857
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 39845
Advantage: 58

Shanghai Huasige Pharmaceutical Technology Co., LTD

Tel: 13611612777
Email: 3627377363@qq.com
Country: China
ProdList: 4015
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: syeu@accelachem.com
Country: China
ProdList: 11015
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Shaanxi Linbang Industrial Co., Ltd

Tel: 17709134430
Email: 2379795542@qq.com
Country: China
ProdList: 4823
Advantage: 58

Anyang Xiyan Technology Co., LTD

Tel: 17525889330
Email: 17525889330@163.com
Country: China
ProdList: 7662
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

630121-86-7, tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylateRelated Search:

tert-Butyl 3-(((trifluoroMethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate

1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-3-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

TERT-BUTYL 3-(((TRIFLUOROMETHYL)SULFONYL)OXY)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE (CAS# 630121-86-7)

1-Boc-3-[[(trifluoromethyl)sulfonyl]oxy]-2,5-dihydropyrrole

630121-86-7

C10H14F3NO5S