ChemicalBook > CAS DataBase List > BI 6015

BI 6015

Product Name: BI 6015
CAS No.: 93987-29-2
Chemical Name: BI 6015
Synonyms: B16015;BI 6015;BI6015 ，E0401;BI-6015, 10 mM in DMSO;HNF4 Antagonist, BI6015;2-methyl-1-(2-methyl-5-nitrophenyl)sulfonylbenzimidazole;2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole;1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-;inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015
CBNumber: CB72695661
Molecular Formula: C15H13N3O4S
Formula Weight: 331.35
MOL File: 93987-29-2.mol

Less

BI 6015 Property

Boiling point:: 570.6±60.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
form: Beige powder
pka: 0.88±0.10(Predicted)
color: Tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI: InChI=1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3
InChIKey: ILVCPQPMRPHZSG-UHFFFAOYSA-N
SMILES: C1(C)N(S(C2=CC([N+]([O-])=O)=CC=C2C)(=O)=O)C2=CC=CC=C2N=1

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 375240
Product name: HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem<br />The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4.
Packaging: 25mg
Price: $226
Updated: 2025/07/31

Cayman Chemical

Product number: 12032
Product name: BI6015
Purity: ≥95%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 12032
Product name: BI6015
Purity: ≥95%
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 12032
Product name: BI6015
Purity: ≥95%
Packaging: 50mg
Price: $360
Updated: 2024/03/01

Tocris

Product number: 4641
Product name: BI6015
Purity: ≥98%(HPLC)
Packaging: 50
Price: $828
Updated: 2021/12/16

Less

BI 6015 Chemical Properties,Usage,Production

Description

BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable.

Uses

BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.

in vivo

BI-6015 (10-30 mg/kg; i.p. once daily for 5 days) induces loss of HNF4α expression and hepatic steatosis in mice^[1].
BI-6015 (10-30 mg/kg; i.p. daily or every other day for 20-57 days) induces apoptosis in a human hepatocellular carcinoma mouse model^[1].

storage

Store at -20°C

References

[1] H WANG. Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.[J]. The Journal of Biological Chemistry, 2000, 275 46: 35953-35959. DOI:10.1074/jbc.m006612200
[2] ALICE KISELYUK. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.[J]. Chemistry & biology, 2012: 806-818. DOI:10.1016/j.chembiol.2012.05.014

BI 6015 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

BI 6015 Suppliers

Canada 1 China 60 India 1 United Kingdom 1 United States 9 Global 72

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

SINO High Goal Chemical Technology Co., Ltd.

Tel: 021-57646680 18306277365
Email: guoxin@chembiobanksh.com
Country: China
ProdList: 2666
Advantage: 58

amyjetsci

Tel: 027-59626688 18771149750
Email: sales@amyjet.com
Country: China
ProdList: 2917
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2935
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

Tel: 025-58851090 17714375163
Email: 2881759498@qq.com
Country: China
ProdList: 13011
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Shenzhen Campbell Biotechnology Co., Ltd.

Tel: 18028747627
Country: CHINA
ProdList: 191
Advantage: 58

Beijing Boning Biotechnology Co., Ltd.

Tel: 13269979963
Email: 1565439254@qq.com
Country: CHINA
ProdList: 195
Advantage: 58

Shanghai Huake Reagent Co., Ltd

Tel: 18121094086
Country: CHINA
ProdList: 169
Advantage: 58

Guangzhou Kegou Biotechnology Co., Ltd.

Tel: 18689410811
Country: CHINA
ProdList: 178
Advantage: 58

Shenzhen Science Biology Co., Ltd.

Tel: 18617181553
Country: CHINA
ProdList: 112
Advantage: 58

Guangzhou Biopark Technology Co., Ltd.

Tel: 020-83808789
Country: CHINA
ProdList: 179
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Wuhan Boot Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6829
Advantage: 58

Shanghai Yihui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yihbio@163.com
Country: CHINA
ProdList: 6184
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 2160
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Shanghai Yuqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 847627550@qq.com
Country: CHINA
ProdList: 6087
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Beijing Chief-East Tech Co.,Ltd (Qwbio)

Tel: --
Fax: --
Email: info@qwbio.com
Country: China
ProdList: 6912
Advantage: 50

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6646
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6525
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Shanghai Gantu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 1920192055@qq.com
Country: CHINA
ProdList: 1843
Advantage: 58

93987-29-2, BI 6015Related Search:

TYRPHOSTIN AG 1296 AG 490 AAL-993 SU 4312

BI 6015

2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole

2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole

inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015

1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-

B16015

BI-6015, 10 mM in DMSO

HNF4 Antagonist, BI6015

2-methyl-1-(2-methyl-5-nitrophenyl)sulfonylbenzimidazole

BI6015 ，E0401

93987-29-2

Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds