BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-

Product Name: BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
CAS No.: 521310-51-0
Chemical Name: BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
Synonyms: MCP110;MCP110, 10 mM in DMSO;N-(4-(benzyloxy)-3-Methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanaMide;astrocytomas,Inhibitor,Raf kinases,colorectal,cancer,MCP110,inhibit,Raf-1,Raf,Ras;BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
CBNumber: CB72706165
Molecular Formula: C33H36N2O3
Formula Weight: 508.65
MOL File: 521310-51-0.mol

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BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Property

storage temp.: Store at 0-8 °C
solubility: Acetonitrile: Soluble
Ethanol: Soluble
Methanol: Soluble
form: Oil
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0084185
Product name: MCP110
Purity: 98.91%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0084185
Product name: MCP110
Purity: 98.91%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0084185
Product name: MCP110
Purity: 98.91%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0084185
Product name: MCP110
Purity: 98.91%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

DC Chemicals

Product number: DC23820
Product name: MCP110
Purity: >98%
Packaging: 1g
Price: $1900
Updated: 2021/12/16

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BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Chemical Properties,Usage,Production

Description

MCP110 is an inhibitor of the protein-protein interaction between Ras and Raf-1.1 It inhibits the interaction between H-Ras and Raf-1 in a yeast two-hybrid assay when used at a concentration of 30 µM. MCP110 (20 µM) inhibits Ras-induced activation of Raf-1 and MEK1 activity in HT-1080 fibrosarcoma cells. In vivo, MCP110 (100 and 600 mg/kg) reduces tumor volume in an SW620 colorectal cancer mouse xenograft model when administered alone or in combination with paclitaxel (Item No. 10461).2WARNING This product is not for human or veterinary use.

References

[1] JURAN KATO-STANKIEWICZ. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 22: 14398-14403. DOI: 10.1073/pnas.222222699
[2] NATALIA SKOBELEVA. In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.[J]. Molecular Cancer Therapeutics, 2007, 6 3: 898-906. DOI: 10.1158/1535-7163.mct-06-0602

BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Suppliers

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521310-51-0, BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-Related Search:

BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-

N-(4-(benzyloxy)-3-Methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanaMide

MCP110

astrocytomas,Inhibitor,Raf kinases,colorectal,cancer,MCP110,inhibit,Raf-1,Raf,Ras

MCP110, 10 mM in DMSO

521310-51-0