ChemicalBook > CAS DataBase List > BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-

BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-

Product Name
BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
CAS No.
521310-51-0
Chemical Name
BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
Synonyms
MCP110;MCP110, 10 mM in DMSO;N-(4-(benzyloxy)-3-Methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanaMide;astrocytomas,Inhibitor,Raf kinases,colorectal,cancer,MCP110,inhibit,Raf-1,Raf,Ras;BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
CBNumber
CB72706165
Molecular Formula
C33H36N2O3
Formula Weight
508.65
MOL File
521310-51-0.mol
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BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Property

storage temp. 
Store at 0-8 °C
solubility 
Acetonitrile: Soluble
Ethanol: Soluble
Methanol: Soluble
form 
Oil
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0084185
Product name
MCP110
Purity
98.91%
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0084185
Product name
MCP110
Purity
98.91%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0084185
Product name
MCP110
Purity
98.91%
Packaging
50mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0084185
Product name
MCP110
Purity
98.91%
Packaging
100mg
Price
$1350
Updated
2021/12/16
DC Chemicals
Product number
DC23820
Product name
MCP110
Purity
>98%
Packaging
1g
Price
$1900
Updated
2021/12/16
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BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Chemical Properties,Usage,Production

Description

MCP110 is an inhibitor of the protein-protein interaction between Ras and Raf-1.1 It inhibits the interaction between H-Ras and Raf-1 in a yeast two-hybrid assay when used at a concentration of 30 µM. MCP110 (20 µM) inhibits Ras-induced activation of Raf-1 and MEK1 activity in HT-1080 fibrosarcoma cells. In vivo, MCP110 (100 and 600 mg/kg) reduces tumor volume in an SW620 colorectal cancer mouse xenograft model when administered alone or in combination with paclitaxel (Item No. 10461).2WARNING This product is not for human or veterinary use.

References

[1] JURAN KATO-STANKIEWICZ. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 22: 14398-14403. DOI: 10.1073/pnas.222222699
[2] NATALIA SKOBELEVA. In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.[J]. Molecular Cancer Therapeutics, 2007, 6 3: 898-906. DOI: 10.1158/1535-7163.mct-06-0602

BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]- Suppliers

China 28 United States 6 Global 34
TargetMol Chemicals Inc.
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521310-51-0, BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-Related Search:


  • BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
  • N-(4-(benzyloxy)-3-Methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanaMide
  • MCP110
  • astrocytomas,Inhibitor,Raf kinases,colorectal,cancer,MCP110,inhibit,Raf-1,Raf,Ras
  • MCP110, 10 mM in DMSO
  • 521310-51-0