ChemicalBook > CAS DataBase List > 2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide

2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide

Product Name
2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide
CAS No.
1380087-89-7
Chemical Name
2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide
Synonyms
Pelabresib;CPI-0610;0610;CPI0160;CP1-0610;Pelabresib (CPI-0610);Pelabresib (CPI-0610) ，S7853;(4S)-6-(4-Chlorophenyl)-1-methyl-4H-isoxazolo[5,4-d][2]benzazepine-4-acetamide;2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide;4H-Isoxazolo[5,4-d][2]benzazepine-4-acetamide, 6-(4-chlorophenyl)-1-methyl-, (4S)-
CBNumber
CB72727784
Molecular Formula
C20H16ClN3O2
Formula Weight
365.81
MOL File
1380087-89-7.mol
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2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Property

Boiling point:
622.8±55.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (273.37 mM; Need ultrasonic)
form 
Powder
pka
16.07±0.40(Predicted)
color 
White to off-white
InChI
InChI=1S/C20H16ClN3O2/c1-11-18-14-4-2-3-5-15(14)19(12-6-8-13(21)9-7-12)23-16(10-17(22)25)20(18)26-24-11/h2-9,16H,10H2,1H3,(H2,22,25)/t16-/m0/s1
InChIKey
GCWIQUVXWZWCLE-INIZCTEOSA-N
SMILES
N1=C(C2=CC=C(Cl)C=C2)C2=CC=CC=C2C2C(C)=NOC=2[C@@H]1CC(N)=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B5887
Product name
BETbromodomaininhibitor
Packaging
10mM(in 1mL DMSO)
Price
$90
Updated
2021/12/16
ApexBio Technology
Product number
B5887
Product name
BETbromodomaininhibitor
Packaging
10mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
BC177446
Product name
CPI 0610 NEW
Packaging
25mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
BC177446
Product name
CPI 0610 NEW
Packaging
50mg
Price
$395
Updated
2021/12/16
Biosynth Carbosynth
Product number
BC177446
Product name
CPI 0610 NEW
Packaging
100mg
Price
$530
Updated
2021/12/16
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2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Chemical Properties,Usage,Production

Uses

BET Bromodomain Inhibitor has be shown to inhibit myeloma cell proliferation in clinically relevant models.

in vivo

Pelabresib (30-60 mg/kg; oral administration; for 28 days; MV-4-11 mouse xenograft model) treatment results in substantial suppression of tumor growth over the time period examined (41%, 80%, and 74% tumor growth inhibition, respectively), without any significant body weight loss in the animals[1].

Animal Model:MV-4-11 mouse xenograft model[1]
Dosage:30 mg/kg once daily, 30 mg/kg twice daily, or 60 mg/kg once daily
Administration:Oral administration; for 28 days
Result:Suppressed of tumor growth, without any significant body weight loss in the animals.

IC 50

BRD4-BD1: 39 nM (IC50)

2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Suppliers

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1380087-89-7, 2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMideRelated Search:

Bet Bromodomain Inhibitor

  • (4S)-6-(4-Chlorophenyl)-1-methyl-4H-isoxazolo[5,4-d][2]benzazepine-4-acetamide
  • CPI0160
  • CPI-0610
  • 2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide
  • 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
  • 4H-Isoxazolo[5,4-d][2]benzazepine-4-acetamide, 6-(4-chlorophenyl)-1-methyl-, (4S)-
  • Pelabresib
  • 0610
  • Pelabresib (CPI-0610)
  • CP1-0610
  • (S)-2-(6-(4-Chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
  • Pelabresib (CPI-0610) ，S7853
  • 1380087-89-7
  • Inhibitors