2-CHLORO-2,2-DIFLUOROACETOPHENONE

Product Name: 2-CHLORO-2,2-DIFLUOROACETOPHENONE
CAS No.: 384-67-8
Chemical Name: 2-CHLORO-2,2-DIFLUOROACETOPHENONE
Synonyms: 2-Chloro-2,2-difluoro-1-phenylethan-1-one;Ethanone, 2-chloro-2,2-difluoro-1-phenyl-;2-Chloro-2,2-d;CHLORODIFLUOROACETOPHENONE;Chlorodifluorobenzophenone;à,à-difluorophenacyl chloride;à-chloro-à,à-difluoroacetophene;A-CHLORO-A,A-DIFLUOROACETOPHENONE;2-CHLORO-2,2-DIFLUOROACETOPHENONE;α,α-Difluoro-α-chloroacetophenone
CBNumber: CB7297366
Molecular Formula: C8H5ClF2O
Formula Weight: 190.57
MOL File: 384-67-8.mol

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2-CHLORO-2,2-DIFLUOROACETOPHENONE Property

Melting point:: 102-103 °C
Boiling point:: 94-96 °C35 mm Hg(lit.)
Density: 1.293 g/mL at 25 °C(lit.)
refractive index: n20/D 1.497(lit.)
Flash point:: 163 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Difficult to mix.
form: liquid
color: Clear, colourless
BRN: 2251448
CAS DataBase Reference: 384-67-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37
RIDADR: UN 3334
WGK Germany: 3
F: 19
Hazard Note: Irritant
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 792373
Product name: 2-Chloro-2,2-difluoroacetophenone
Purity: 95%
Packaging: 10g
Price: $308
Updated: 2025/07/31

Sigma-Aldrich

Product number: 792373
Product name: 2-Chloro-2,2-difluoroacetophenone
Purity: 95%
Packaging: 1g
Price: $63.2
Updated: 2023/06/20

TRC

Product number: C423215
Product name: 2-Chloro-2,2-difluoroacetophenone
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C423215
Product name: 2-Chloro-2,2-difluoroacetophenone
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD30535
Product name: 2,2-Difluoro-2-chloroacetophenone
Packaging: 2g
Price: $76
Updated: 2021/12/16

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2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

reaction suitability

reaction type: C-C Bond Formation

2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-2,2-DIFLUOROACETOPHENONE Suppliers

China 103 Europe 2 France 1 Germany 2 India 2 Russia 1 Switzerland 2 United Kingdom 7 United States 14 Global 134

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View Lastest Price from 2-CHLORO-2,2-DIFLUOROACETOPHENONE manufacturers

Honest Joy Holdings Limited

Product: 2-Chloro-2,2-difluoroacetophenone 384-67-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-02-21

384-67-8, 2-CHLORO-2,2-DIFLUOROACETOPHENONERelated Search:

CHLORODIFLUOROACETOPHENONE

alpha,alpha-Difluorophenacyl chloride

2-CHLORO-2,2-DIFLUOROACETOPHENONE

A-CHLORO-A,A-DIFLUOROACETOPHENONE

ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE

ChlorodifluoroMethyl phenyl ketone

2-Chloro-2,2-d

2-chloro-2,2-difluoro-1-phenylethanone

2-chloro-2,2-difluoro-1-phenyl-ethanone

2-Chloro-2,2-difluoro-1-phenylethan-1-one

à,à-difluorophenacyl chloride

à-chloro-à,à-difluoroacetophene

2-Chloro-2,2-difluoroacetophenone 97%

2-Chloro-2,2-difluoroacetophenone97%

2-CHLORO-2,2-DIFLUOROACETOPHENE, 96%

1-Phenyl-2,2-difluoro-2-chloroethanone

Phenyl(chlorodifluoromethyl) ketone

α,α-Difluoro-α-chloroacetophenone

Ethanone, 2-chloro-2,2-difluoro-1-phenyl-

Chlorodifluorobenzophenone

384-67-8

C6H5COCF2Cl

Fluorine series