4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid

Product Name: 4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid
CAS No.: 1402612-64-9
Chemical Name: 4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid
Synonyms: KT203;KT-203,KT203;KT203 >=98% (HPLC);KT203, 10 mM in DMSO;4′-(1-(2-benzylpiperidine-1-carbonyl)-1H-1,2,3-triazol-4-yl)-[1,1′-biphenyl]-3-carboxylic acid;4'-[1-(2-benzylpiperidine-1-carbonyl)-1H-1,2,3-triazol-4-yl]-[1,1'-biphenyl]-3-carboxylic acid;4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid;[1,1'-Biphenyl]-3-carboxylic acid, 4'-[1-[[2-(phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-
CBNumber: CB72985201
Molecular Formula: C28H26N4O3
Formula Weight: 466.53
MOL File: 1402612-64-9.mol

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4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid Property

Boiling point:: 724.3±62.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid
pka: 4.02±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1250
Product name: KT203
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1250
Product name: KT203
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $314
Updated: 2025/07/31

Cayman Chemical

Product number: 14819
Product name: KT203
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14819
Product name: KT203
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 14819
Product name: KT203
Purity: ≥98%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

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4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid Chemical Properties,Usage,Production

Uses

KT203 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.31 nM in Neuro2A cells[1].

Biological Activity

kt203 is an abhd6 inhibitor.abhd6, a unique and highly conserved enzyme in mammals, is prominently expressed in brain, liver, kidney, and brown adipose tissue based on global gene expression analysis and activitybased protein profiling (abpp).

in vitro

the in-vitro potency of kt203 was studied and it was found that kt203 was able to potently inhibit abhd6 as measured by gelbased competitive abpp and 2-ag hydrolysis assays. moreover, the in-situ potency was then measured by treating neuro2a cells with varying concentrations of kt203 for 4 h and the results showed that kt203 inhibited abhd6 with ic50 values in the subnanomolar range [1].

in vivo

in a previous animal study, mice were treated intraperitoneally with kt203 at various doses (0.1-1 mg/kg) for 4 h. results showed that kt203 had near-complete blockade of abhd6 in the liver at the highest dose tested. at lower doses, kt203 showed about 80% inhibition of abhd6 in the liver. notably, kt203 exhibited impressive selectivity in the mouse liver even at higher doses, showing little cross-reactivity against the numerous carboxylesterase enzymes that are common off-targets of mechanism-based sh inhibitors in rodents. in addition, kt203 showed good selectivity against other brain and liver shs as judged by gelbased abpp, suggesting a single major off-target, carboxylesterase-1 (ces1) [1].

IC 50

< 5 nm

References

[1] hsu kl, tsuboi k, chang jw, whitby lr, speers ae, pugh h, cravatt bf. discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (abhd6). j med chem. 2013 nov 14;56(21):8270-9.

4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid Suppliers

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1402612-64-9, 4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acidRelated Search:

4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid

KT203

4′-(1-(2-benzylpiperidine-1-carbonyl)-1H-1,2,3-triazol-4-yl)-[1,1′-biphenyl]-3-carboxylic acid

[1,1'-Biphenyl]-3-carboxylic acid, 4'-[1-[[2-(phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-

KT203 >=98% (HPLC)

KT-203,KT203

4'-[1-(2-benzylpiperidine-1-carbonyl)-1H-1,2,3-triazol-4-yl]-[1,1'-biphenyl]-3-carboxylic acid

KT203, 10 mM in DMSO

1402612-64-9