L-LEUCIC ACID

Product Name: L-LEUCIC ACID
CAS No.: 13748-90-8
Chemical Name: L-LEUCIC ACID
Synonyms: Hydroxyisocaproic acid;2-HYDROXY-3-METHYLPENTANOIC ACID;LEUCIC ACID;2-HYDROXY-3-METHYLVALERIC ACID;(s)-pentanoicaci;(S)-(-)-2-HYDROXYISOCAPROIC ACID;L-HICA;L-LEUCIC ACID;(S)-Leucic acid;L-LeucicAcid>
CBNumber: CB7298813
Molecular Formula: C6H12O3
Formula Weight: 132.16
MOL File: 13748-90-8.mol

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L-LEUCIC ACID Property

Melting point:: 78-80 °C(lit.)
Boiling point:: 277.83°C (rough estimate)
Density: 1.0160 (rough estimate)
refractive index: -26 ° (C=2, 1 %NaOH)
storage temp.: Sealed in dry,Room Temperature
solubility: Aqueous Base (Slightly), DMSO (Sparingly), Water (Slightly)
pka: 3.86±0.21(Predicted)
form: Solid
color: White to Off-White
optical activity: [α]22/D 26.3°, c = 1 in 1 M NaOH
Water Solubility: almost transparency
InChI: InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKey: LVRFTAZAXQPQHI-YFKPBYRVSA-N
SMILES: C(O)(=O)[C@@H](O)CC(C)C
LogP: 0.710
CAS DataBase Reference: 13748-90-8(CAS DataBase Reference)
EPA Substance Registry System: Pentanoic acid, 2-hydroxy-4-methyl-, (2S)- (13748-90-8)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219827
Product name: (S)-(?)-2-Hydroxyisocaproic acid
Purity: 98%
Packaging: 1g
Price: $51.89
Updated: 2025/07/31

TCI Chemical

Product number: L0026
Product name: L-Leucic Acid
Purity: >99.0%(T)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: L0026
Product name: L-Leucic Acid
Purity: >99.0%(T)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: L0026
Product name: L-Leucic Acid
Purity: >99.0%(T)
Packaging: 25g
Price: $224
Updated: 2025/07/31

TRC

Product number: L330085
Product name: L-Leucic Acid
Packaging: 5g
Price: $95
Updated: 2021/12/16

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L-LEUCIC ACID Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.

Definition

ChEBI: The (S)-enantiomer of 2-hydroxy-4-methylpentanoic acid. Derived from the metabolism of the branched-chain amino acids, it belongs to the 2-hydroxycarboxylic acid group of amino acid metabolites.

Synthesis

61-90-5

13748-90-8

GENERAL STEPS: L-leucine (24.92 g, 0.189 mol) was dissolved in 1.25 M H2SO4 (125 mL), stirred and cooled to 0°C. An aqueous solution of sodium nitrite (19.73 g, 0.286 mol) (100 mL) was added dropwise with stirring. After addition, the reaction mixture was continued to be stirred at 0°C for 2 hours, and then brought to room temperature and stirred for 15 hours. After completion of the reaction, the reaction mixture was extracted with ether (6 x 75 mL). The organic layers were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to remove the ether to give the crude product L-α-hydroxyisocaproic acid (2c or 2d). The crude product was purified by solvent recrystallization from hexane-ether mixture.

IC 50

Microbial Metabolite; Human Endogenous Metabolite

References

[1] Organic Letters, 2012, vol. 14, # 16, p. 4246 - 4249
[2] Organic Letters, 2006, vol. 8, # 14, p. 2993 - 2996
[3] European Journal of Organic Chemistry, 2009, # 31, p. 5390 - 5405
[4] ACS Chemical Neuroscience, 2013, vol. 4, # 8, p. 1204 - 1216
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 1, p. 11 - 14

L-LEUCIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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L-LEUCIC ACID Suppliers

Americas 1 Belgium 1 China 161 Europe 2 France 1 Germany 3 India 4 Japan 2 Switzerland 2 The Netherlands 1 United Kingdom 5 United States 27 Global 210

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View Lastest Price from L-LEUCIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-LEUCIC ACID 13748-90-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: 2-Hydroxy-2-methylbutyric acid 13748-90-8
Price: US $20.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-02

13748-90-8, L-LEUCIC ACIDRelated Search:

Vincristine sulfate Brovincamine Vinflunine OBACUNON Valrubicin Limonin L-LEUCIC ACID Nomilin Azadirachtin (1S)-(-)-Camphanic acid Vincamine 2-HYDROXY-4-METHYLVALERIC ACID,DL-2-HYDROXY-4-METHYLVALERIC ACID,DL-LEUCIC ACID DL-LEUCIC ACID 4-Methylvaleric acid Formyl-leurosine DEACETYLNOMILIN RUTAEVIN DL-2-Hydroxy-4-methylvaleric Acid Ethyl Ester,DL-Leucic Acid Ethyl Ester

(s)-pentanoicaci

(S)-(-)-2-HYDROXYISOCAPROIC ACID

(S)-2-HYDROXY-4-METHYLVALERIC ACID

2-HYDROXY-3-METHYLVALERIC ACID

2-HYDROXY-3-METHYLPENTANOIC ACID

L-2-hydroxy-4-methylvaleric acid

LEUCIC ACID

L-LEUCIC ACID

L-ALPHA-HYDROXYISOCAPROIC ACID

(S)-(-)-2 HYDROXYSOCAPROIC ACID,98%

Pentanoic acid, 2-hydroxy-4-methyl-, (2S)-

(2S)-2-hydroxy-4-methylpentanoic acid

Hydroxyisocaproic acid

S-2-Hydroxy-4-methylpentanoic acid

(S)-Leucic acid

2-Hydroxy-4-methylvaleric acid, L-2-Hydroxy-4-methylpentanoic acid, L-Leucic acid

(2S)-2-Hydroxy-4-methylvaleric acid

(S)-4-Methyl-2-hydroxyvaleric acid

L-a-Hydroxyisocaproic acid

L-LEUCIC ACID ( AKA ) 2-HYDROXY ISOCAPROIC ACID

L-alpha-Hydroxyisocaproic acid calcium

L-HICA

(S)-(-)-2-Hydroxyisocaproic acid 98%

(S)-iso-PrCH2CH(OH)CO2H, L-leucic acid, L-O-leucine, H-Hica-OH, L-Hic, OLeu, (S)-(+)-2-hydroxy-4-methylpentanoic acid

<small>L</small>-Leucic Acid

L-LeucicAcid&gt

(S)-2-hydroxy-4-methylpentanoicaci

L-α-Hydroxyisocaproic acid

(S)-2-Hydroxy-4-methy (pentanoic acid

(S)-α-hydroxyisocaproic acid

(S)-Leucic acid, 10 mM in DMSO

(<i>S</i>)-(?)-2-Hydroxyisocaproic acid

13748-90-8

CH32CHCH2CHOHCO2H

C4H9CHOHCOOH

CH32CHCH2CHOHCOOH

Carboxylic Acids

Asymmetric Synthesis

Organic Building Blocks

Chiral Building Blocks

Carboxylic Acids (Chiral)

API intermediates

Carboxylic Acids (Chiral)

Chiral Building Blocks

Synthetic Organic Chemistry

chiral