)-CPSI 1306

Product Name: )-CPSI 1306
CAS No.: 1309793-47-2
Chemical Name: )-CPSI 1306
Synonyms: )-CPSI 1306;(±)-CPSI-1306, 10 mM in DMSO;2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one;Ethanone, 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-;2-[3-(3-(2,4-Difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)ethanone
CBNumber: CB73036964
Molecular Formula: C15H16F2N2O3
Formula Weight: 310.3
MOL File: 1309793-47-2.mol

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)-CPSI 1306 Property

Boiling point:: 453.3±55.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:22.34(Max Conc. mg/mL);71.99(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.64(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);96.68(Max Conc. mM)
Ethanol:3.1(Max Conc. mg/mL);9.99(Max Conc. mM)
form: A crystalline solid
pka: -0.91±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29905
Product name: CPSI-1306
Packaging: 10mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 29905
Product name: CPSI-1306
Packaging: 25mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 29905
Product name: CPSI-1306
Packaging: 5mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 29905
Product name: CPSI-1306
Packaging: 50mg
Price: $220
Updated: 2024/03/01

TRC

Product number: C781508
Product name: (±)-CPSI1306
Packaging: 10mg
Price: $210
Updated: 2021/12/16

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)-CPSI 1306 Chemical Properties,Usage,Production

Uses

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).

in vivo

Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease^[1]. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation^[2].

storage

Store at -20°C

References

[1] Sanchez-Zamora Y, et al. Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus. FASEB J. 2010 Jul;24(7):2583-90. DOI:10.1096/fj.09-147066
[2] Nagarajan P, et al. MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma. Mol Cancer Res. 2014 Sep;12(9):1292-302. DOI:10.1158/1541-7786.MCR-14-0255-T

)-CPSI 1306 Preparation Products And Raw materials

Raw materials

Preparation Products

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)-CPSI 1306 Suppliers

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1309793-47-2, )-CPSI 1306Related Search:

)-CPSI 1306

2-[3-(3-(2,4-Difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)ethanone

Ethanone, 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-

2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one

(±)-CPSI-1306, 10 mM in DMSO

1309793-47-2