)-CPSI 1306
- Product Name
- )-CPSI 1306
- CAS No.
- 1309793-47-2
- Chemical Name
- )-CPSI 1306
- Synonyms
- )-CPSI 1306;(±)-CPSI-1306, 10 mM in DMSO;2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one;Ethanone, 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-;2-[3-(3-(2,4-Difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)ethanone
- CBNumber
- CB73036964
- Molecular Formula
- C15H16F2N2O3
- Formula Weight
- 310.3
- MOL File
- 1309793-47-2.mol
)-CPSI 1306 Property
- Boiling point:
- 453.3±55.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:22.34(Max Conc. mg/mL);71.99(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.64(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);96.68(Max Conc. mM)
Ethanol:3.1(Max Conc. mg/mL);9.99(Max Conc. mM) - form
- A crystalline solid
- pka
- -0.91±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29905
- Product name
- CPSI-1306
- Packaging
- 10mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 29905
- Product name
- CPSI-1306
- Packaging
- 25mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 29905
- Product name
- CPSI-1306
- Packaging
- 5mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 29905
- Product name
- CPSI-1306
- Packaging
- 50mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- C781508
- Product name
- (±)-CPSI1306
- Packaging
- 10mg
- Price
- $210
- Updated
- 2021/12/16
)-CPSI 1306 Chemical Properties,Usage,Production
Uses
(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).
in vivo
Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease[1]. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation[2].
storage
Store at -20°C
References
[1] Sanchez-Zamora Y, et al. Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus. FASEB J. 2010 Jul;24(7):2583-90. DOI:10.1096/fj.09-147066
[2] Nagarajan P, et al. MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma. Mol Cancer Res. 2014 Sep;12(9):1292-302. DOI:10.1158/1541-7786.MCR-14-0255-T
)-CPSI 1306 Preparation Products And Raw materials
Raw materials
Preparation Products
)-CPSI 1306 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77