Defination In the body Medical uses Mechanism of action
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Adenosine

Defination In the body Medical uses Mechanism of action
Product Name
Adenosine
CAS No.
58-61-7
Chemical Name
Adenosine
Synonyms
AR;(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;Adenosin;ADENINENUCLEOSIDE;Androgen receptor;2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;Adesine;Adenocard;Adenoscan;(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
CBNumber
CB7304660
Molecular Formula
C10H13N5O4
Formula Weight
267.24
MOL File
58-61-7.mol
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Adenosine Property

Melting point:
234-236 °C (lit.)
Boiling point:
410.43°C (rough estimate)
alpha 
D11 -61.7° (c = 0.706 in water); 9D -58.2° (c = 0.658 in water)
Density 
1.3382 (rough estimate)
refractive index 
1.7610 (estimate)
storage temp. 
2-8°C
solubility 
Slightly soluble in water, soluble in hot water, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute mineral acids.
form 
Crystalline Powder
pka
3.6, 12.4(at 25℃)
color 
White
PH
3.59;12.5
biological source
synthetic (organic)
optical activity
[α]20/D 70±3°, c = 2% in 5% NaOH
Water Solubility 
Soluble in water, ammonium hydroxide and dimethyl sulfoxide. Insoluble in ethanol.
λmax
257 (pH 1);260 (pH 6)
Merck 
14,153
BRN 
93029
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
OIRDTQYFTABQOQ-KQYNXXCUSA-N
LogP
-0.755 (est)
CAS DataBase Reference
58-61-7(CAS DataBase Reference)
NIST Chemistry Reference
adenosine(58-61-7)
EPA Substance Registry System
Adenosine (58-61-7)
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-26
WGK Germany 
2
RTECS 
AU7175000
10-23
TSCA 
Yes
HS Code 
29389090
Hazardous Substances Data
58-61-7(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: > 20gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB1306176
Product name
ANTI-ANDROGEN RECEPTOR (ANDR) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
400 μL
Price
$496
Updated
2025/07/31
Sigma-Aldrich
Product number
RAB0019
Product name
Human Amphiregulin ELISA Kit
Purity
for serum, plasma, cell culture supernatant and urine
Packaging
1 kit
Price
$569
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL80977
Product name
Adenosine
Purity
phyproof? Reference Substance
Packaging
100MG
Price
$239
Updated
2025/07/31
Sigma-Aldrich
Product number
A0230200
Product name
Adenosine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
50 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
01890
Product name
Adenosine
Packaging
5g
Price
$48.3
Updated
2025/07/31
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Adenosine Chemical Properties,Usage,Production

Defination

Adenosine is a natural nucleotide, which is the intermediate product of metabolism, chemically 6-amino-9-beta-D-ribofuranosyl-9-H-purine. Adenosine is one of the important active components in the body, helps in cellular energy transfer by forming molecules like adenosine triphosphate (ATP) and adenosine diphosphate (ADP). It also plays a role in signaling various pathways and functions in the body by forming signally molecules like cyclic adenosine monophosphate (cAMP).

In the body

Adenosine in the body
Function
Brain
Promoting sleep and suppresses arousal acting as a central nervous system depressant.
Heart
Causing dilation of the coronary blood vessels that Improving blood circulation to the heart; Increasing the diameter of blood vessels in the peripheral organs; Decreasing heart rate
Blood
Broken down by adenosine deaminase. By taking medicine like Dipyridamole(inhibitor of adenosine deaminase), it can improve blood flow through the coronary blood vessels that supply the heart muscles.
Kidneys, lungs and liver
In the kidneys adenosine decreases renal blood flow and decrease the production of rennin from the kidneys. In the lungs it causes constriction of airways and in the liver it leads to constriction of blood vessels and increases breakdown of glycogen to form glucose.

Medical uses

Adenosine has a role in the expansion of coronary artery and myocardial contractility, is clinically applied in the treatment of angina, hypertension, cerebrovascular disorders, stroke sequelae, muscular atrophy, etc. It is also given intravenously (by IV) for treating supraventricular tachycardia and Tl myocardial imaging. It is also used for cardiac stress tests.  Side effects:
Since the half-life of this compound is less than 10 seconds, its side effects are usually transient. However, side effects are common, and include flushing, headache, chest discomfort, bronchoconstriction, and occasionally hypotension. Hepatic and renal failure and other drugs except dipyridamole seem to have little effect on the action of adenosine.    Adenosine dose

   

Mechanism of action

Its function is realized through the activation of the adenosine receptor (A receptor). Adenosine activates G protein coupled potassium channels by binding to the A receptor which makes increasing the outflow of K+ and cell membrane hyperpolarization so as to decrease the automaticity in the atrium, sinoatrial node and atrioventricular node. It can also significantly increase the level of cGMP , prolong ERP of the atrioventricular node and slowing of atrioventricular, depress sympathetic nervous or early and delayed after depolarization induced by isoproterenol and then plays an effective role in arrhythmia. This product has not been classified in I~IV anti arrhythmia medicine.

Adenosine receptor

  • A1 receptors, which are found in cardiomyocytes and which are responsible for the inhibition of adenylyl cylase activity which lowers cyclic adenosine monophosphate (AMP) results in sinus slowing, increase in AV node conduction delay, and antagonism of the effects of catecholamines;
  • A2 receptors, which are found in endothelial cells and vascular smooth muscle and are responsible for the enhancement of adenylyl cylase activity and increased cyclic AMP which relaxes smooth muscle. Both negative chronotropic and dromotropic effects of adenosine are cyclic AMP independent (direct action) as well cyclic AMP dependent (indirect action).

Description

Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Adenosine works in the energy transfer-as adenosine triphosphate (ATP) and adenosine diphosphate (ADP)-as well as in signal transduction as cyclic adenosine monophosphate, cAMP. It shows neuromodulatory, cytoprotective, anti-inflammatory and cardioprotective actions.

Chemical Properties

Adenosine is an important nucleoside composed of adenine and ribose. White, crystalline, odorless powder, mild, saline, or bitter taste, quite soluble in hot water, practically insoluble in alcohol. Formed by isolation following hydrolysis of yeast nucleic acid.

Uses

adenosine is an amino acid. Studies indicate anti-wrinkle and skinsmoothing capacities. Although little is written about its direct skin benefit, adenosine plays an important role in biochemical processes. As adenosine triphosphate (ATP) and adenosine diphosphate (ADP), it is involved in energy transfer, and as cyclic adenosine monophosphate (cAMP) in signal transduction.

Application

Adenosine can serve as a diagnostic or therapeutic agent. Diagnostically, adenosine is one pharmaceutical agent used in a myocardial perfusion stress imaging study for its vasodilatory effects. Therapeutically, adenosine is used for its antiarrhythmic properties in supraventricular tachycardia (SVT) and can function as a diagnostic tool, depending on the type of SVT.

Definition

ChEBI: Adenosine is a ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond. It has a role as an anti-arrhythmia drug, a vasodilator agent, an analgesic, a human metabolite and a fundamental metabolite. It is a purines D-ribonucleoside and a member of adenosines. It is functionally related to an adenine.

brand name

Adenocard (Astellas); Adenoscan (Astellas).

Origin

Adenosine may be generated intracellularly in the central nervous system from degradation of AMP or from the hydrolysis of S-adenosyl homocysteine, and then exit via bi-directional nucleoside transporters, or extracellularly by the metabolism of released nucleotides. Inactivation of extracellular adenosine occurs by transport into neurons or neighboring cells, followed by either phosphorylation to AMP by adenosine kinase or deamination to inosine by adenosine deaminase[1].

Biological Functions

Adenosine regulates multiple physiological and pathophysiological processes, by acting both through G-protein coupled adenosine receptors and intracellularly. It modulates neuronal plasticity, astrocytic activity , learning and memory, food intake, motor function, sleep/wake cycle, pain, immunosupression, proliferation, and aging. Adenosine is involved in ischemia and stroke, epilepsy, and neurodegenerative pathologies such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). Extracellular adenosine, interacting with P1 receptors (A1R, A2AR, A2BR, and A3R) regulates metabolism through different signaling pathways[1].

Biological Functions

[1] Mercedes Garcia-Gil. “Metabolic Aspects of Adenosine Functions in the Brain.” Frontiers in Pharmacology (2021): 672182.

General Description

Adenosine is a purine nucleoside and a building block of RNA and many other biomolecules such as adenosine triphosphate and nicotinamide adenine dinucleotide. In the extracellular space, ecto-5′-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation.

Biological Activity

Neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes.

Biochem/physiol Actions

Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti?inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).

Clinical Use

Adenosine (Adenocard) is an endogenous nucleoside that is a product of the metabolism of adenosine triphosphate. It is used for the rapid termination of supraventricular arrhythmias following rapid bolus dosing.
Adenosine is approved for the acute management and termination of supraventricular tachyarrhythmias, including A-V nodal reentrant tachycardia and A-V reciprocating tachycardia. Adenosine may be helpful in the diagnosis of atrial flutter.

Side effects

Adverse reactions to the administration of adenosine are fairly common; however, the short half-life of the drug limits the duration of such events.The most common adverse effects are flushing, chest pain, and dyspnea. Adenosine may induce profound bronchospasm in patients with known reactive airway disease. The mechanism for bronchospasm is unclear, and the effect may last for up to 30 minutes despite the short half-life of the drug.

Drug interactions

Metabolism of adenosine is slowed by dipyridamole, indicating that in patients stabilized on dipyridamole the therapeutically effective dose of adenosine may have to be increased. Methylxanthines antagonize the effects of adenosine via blockade of the adenosine receptors.

Metabolism

It is impossible to study adenosine in classical pharmacokinetic studies, since it is present in various forms in all the cells of the body. An efficient salvage and recycling system exists in the body, primarily in erythrocytes and blood vessel endothelial cells. The halflife in vitro is estimated to be less than 10 seconds, and may be even shorter in vivo.

storage

-20°C

Purification Methods

Crystallise adenosine from distilled water and dry it at 110o. It has been purified via the picrate, where ethanolic picric acid is added to adenosine and the picrate is filtered off and recrystallised from EtOH. It has m 180-185o(dec). Adenosine is recovered by dissolving 0.4g of the picrate in 80mL of hot H2O, treated with a small quantity of Dowex 1 anion exchange resin in the chloride form, and the resin is filtered off. The filtrate is treated with more resin and filtered again. One equivalent of aqueous NaOH is added to the colourless filtrate which is evaporated to 4mL and cooled to give 0.176g of adenosine m 236o. [Davoll et al. J Chem Soc 967 1948, Davoll & Lowy J Am Chem Soc 73 1650 1951, Beilstein 26 III/IV 3598.]

Precautions

Patients with second- or third-degree A-V block should not receive adenosine. As indicated previously, the use of adenosine in asthmatic patients may exacerbate the asthmatic symptoms.

Adenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Adenosine manufacturers

WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)
Product
Adenosine Ar 58-61-7
Price
US $0.00-0.00/kg
Min. Order
25kg
Purity
≥99%
Supply Ability
2tons
Release date
2025-08-19
WUHAN FORTUNA CHEMICAL CO., LTD
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Adenosine 58-61-7
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US $0.00-0.00/kg
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1kg
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98%min
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10 Tons
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2025-07-15
Anhuyan (Hainan) Biotechnology Co., LTD
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Adenosine 58-61-7
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US $0.00/G/KG
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1G/KG
Purity
99%
Supply Ability
100000000KG
Release date
2025-04-23

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  • Adenosine, 99%, substrate of adenosine deaminase
  • Adenosine - Endotoxin level below 100 EU/g
  • Adenosine - Endotoxin level below 1000 EU/g
  • 2,3,5-Tri-O-acetyl &alpha
  • NanoLiposomal Adenosine, Water-Soluble Adenosine
  • ADENINE-9-D-RIBOFURANOSIDE
  • Adenine-9-B-D-Ribofuranoside
  • (-)-ADENOSINE, 99+%
  • ADENOSINE FREE BASE CELL CULTURE TESTED
  • Adenine-9-β-D-ribofur
  • AdenosineForBiochemistry
  • Adenosine,>98%
  • 9-bate-D-Ribofuranosyladenine free base
  • Adenosine,9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside
  • Adenosine (200 mg)
  • 6-amino-9-beta-d-ribofuranosyl-9h-purine
  • 6-Amino-9beta-D-ribofuranosyl-9H-purine
  • 9-beta-D-Ribofuranosidoadenine
  • 9-beta-D-Ribofuranosyl-9H-purin-6-amine
  • 9H-Purin-6-amine, 9-beta-d-ribofuranosyl-
  • Adenocard
  • Adenocor
  • Adenoscan
  • Adenosin
  • beta-Adenosine
  • beta-d-Adenosine
  • beta-d-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-
  • beta-d-Ribofuranoside, adenine-9