4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

Product Name: 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
CAS No.: 205448-64-2
Chemical Name: 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
Synonyms: lenvaint-B;idene)methyL;4-(((2,2-dimethyL;Lenvatinib Impurity 120;)amino)-2-methoxybenzoate;-4,6-dioxo-1,3-dioxan-5-yL;METHYL4-[(2,2-DIMETHYL-4,6;methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino);4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)-2-methoxybenzoate;Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
CBNumber: CB73116376
Molecular Formula: C16H17NO7
Formula Weight: 335.31
MOL File: 205448-64-2.mol

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4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Property

Boiling point:: 547.8±50.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: -3?+-.0.40(Predicted)
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D481133
Product name: 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoicAcidMethylEster
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 4469DA
Product name: Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
Packaging: 250mg
Price: $103
Updated: 2021/12/16

AK Scientific

Product number: 4469DA
Product name: Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
Packaging: 1g
Price: $114
Updated: 2021/12/16

Ambeed

Product number: A100807
Product name: Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
Purity: 97%
Packaging: 5g
Price: $125
Updated: 2021/12/16

Chemenu

Product number: CM251202
Product name: Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
Purity: 97%
Packaging: 5g
Price: $281
Updated: 2021/12/16

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4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Chemical Properties,Usage,Production

Synthesis

15568-85-1

27492-84-8

205448-64-2

The general procedure for the synthesis of methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)methylamino)-2-methoxybenzoate from 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxane-4,6-dione and 2-methoxy-4-aminobenzoic acid methyl ester was as follows: first, 2-methoxy-4-aminobenzoic acid methyl ester (14.15 g, 78 mmol) was suspended in isopropanol and heated at 50 °C. Subsequently, 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxohexane-4,6-dione (14.8 g, 80 mmol) was added in batches over 10 min. The reaction mixture was heated to reflux for 30 minutes. After completion of the reaction, the mixture was cooled to room temperature and the precipitate formed was collected by filtration. The precipitate was washed with isopropanol and dried under vacuum to afford the target product 5-((3-methoxy-4-methoxycarbonylanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (25.2 g, 96% yield).

References

[1] Patent: US6809097, 2004, B1. Location in patent: Page column 67
[2] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 48
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1649 - 1667
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1668 - 1680

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Preparation Products And Raw materials

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4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Suppliers

China 77 India 1 United States 2 Global 80

Synthonix Inc

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View Lastest Price from 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester manufacturers

Moxin Chemicals

Product: Lenvatinib Impurity 205448-64-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000
Release date: 2025-03-20

Nanjing Fred Technology Co., Ltd

Product: 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]-dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester 205448-64-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-19

205448-64-2, 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl esterRelated Search:

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate

methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)

METHYL4-[(2,2-DIMETHYL-4,6

lenvaint-B

)amino)-2-methoxybenzoate

4-(((2,2-dimethyL

-4,6-dioxo-1,3-dioxan-5-yL

idene)methyL

Benzoic acid, 4-[[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino]-2-methoxy-, methyl ester

4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)-2-methoxybenzoate

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester 4-

Lenvatinib Impurity 120

methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoatemethyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate

205448-64-2