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Todralazine hydrochloride

Product Name
Todralazine hydrochloride
CAS No.
3778-76-5
Chemical Name
Todralazine hydrochloride
Synonyms
binazin;binazine;apirachol;ECARAZINE;Apiracohl;Hydrapron;TODRALAZINE HCL;621-bthydrochloride;ECARAZINE HYDROCHLORIDE;TODRALAZINE HYDROCHLORIDE
CBNumber
CB7312164
Molecular Formula
C11H13ClN4O2
Formula Weight
268.7
MOL File
3778-76-5.mol
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
FE2778600
Toxicity
LD50 i.p. in mice: 500 mg/kg (Parravincini)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20893
Product name
Todralazine (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$68
Updated
2021/03/22
Cayman Chemical
Product number
20893
Product name
Todralazine (hydrochloride)
Purity
≥98%
Packaging
500mg
Price
$129
Updated
2021/03/22
Cayman Chemical
Product number
20893
Product name
Todralazine (hydrochloride)
Purity
≥98%
Packaging
1g
Price
$245
Updated
2021/03/22
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Todralazine hydrochloride Chemical Properties,Usage,Production

Originator

Prorazin,Teisan

Uses

Antihypertensor

Manufacturing Process

A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol is cooled, under agitation to a temperature of -10°C. To the suspension is added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in 150 ml of anhydrous ethanol and the reaction mass is agitated for about 2 hours, maintaining a temperature of -10°C. The temperature is then raised to about 20°C and stirring is continued for 2 hours, whereupon heating is applied and boiling is maintained for 15 min. After cooling, the separated 1- hydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water, and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol. 11.5 g of a raw product are obtained which for the purpose of purification are dissolved in 15 ml of boiling water with an addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1- carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are obtained.

Therapeutic Function

Antihypertensive

Todralazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Todralazine hydrochloride Suppliers

BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
9942
Advantage
65
BOC Sciences
Tel
1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19753
Advantage
58

3778-76-5, Todralazine hydrochlorideRelated Search:


  • apirachol
  • binazin
  • binazine
  • carbazicacid,3-(1-phthalazinyl)-,ethylester,monohydrochloride
  • hydrazinecarboxylicacid,2-(1-phthalazinyl)-,ethylester,monohydrochloride
  • TODRALAZINE HYDROCHLORIDE
  • 2-(1-PHTHALAZINYL)-HYDRAZINECARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
  • ethyl 3-(phthalazin-1-yl)carbazate hydrochloride
  • ECARAZINE
  • ECARAZINE HYDROCHLORIDE
  • TODRALAZINE HCL
  • Apiracohl
  • Hydrapron
  • Todralazine hydrochloride hydrate
  • ethyl N-(phthalazin-1-ylamino)carbamate hydrochloride
  • N-(phthalazin-1-ylamino)carbamic acid ethyl ester hydrochloride
  • ethyl 2-(phthalazin-1-yl)hydrazinecarboxylate hydrochloride
  • 621-bthydrochloride
  • 3778-76-5
  • C11H13ClN4O2
  • C11H12N4O2HCl
  • C11H11N4O2HCL
  • Antihypertensive
  • Analytical Chromatography Product Catalog
  • Analytical Standards
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