MMV-390048

Product Name: MMV-390048
CAS No.: 1314883-11-8
Chemical Name: MMV-390048
Synonyms: MMV 048;MMV-390048;MMV390048 (MMV 048;MMV390048, 10 mM in DMSO;5-(4-(Methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine;[3,3'-Bipyridin]-2-amine, 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-;MMV-390048,inhibit,PI4 kinases,Parasite,Inhibitor,MMV390048,MMV 390048,Phosphatidylinositol 4 kinases,PI4K
CBNumber: CB73122023
Molecular Formula: C18H14F3N3O2S
Formula Weight: 393.38
MOL File: 1314883-11-8.mol

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MMV-390048 Property

Boiling point:: 534.4±50.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 100 mg/mL (254.21 mM; Need ultrasonic)
form: Solid
pka: 3.79±0.50(Predicted)
color: White to off-white
InChI: InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
InChIKey: RTJQABCNNLMCJF-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(C2=CC=C(S(C)(=O)=O)C=C2)C=C1C1=CC=C(C(F)(F)F)N=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M425523
Product name: MMV-390048
Packaging: 1g
Price: $75
Updated: 2021/12/16

DC Chemicals

Product number: DC21333
Product name: MMV390048
Purity: >98%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

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MMV-390048 Chemical Properties,Usage,Production

Uses

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].

IC 50

Plasmodium

References

[1] Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. DOI:10.1126/scitranslmed.aad9735

MMV-390048 Preparation Products And Raw materials

Raw materials

Preparation Products

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MMV-390048 Suppliers

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1314883-11-8, MMV-390048Related Search:

MMV 048

MMV-390048

[3,3'-Bipyridin]-2-amine, 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-

MMV-390048,inhibit,PI4 kinases,Parasite,Inhibitor,MMV390048,MMV 390048,Phosphatidylinositol 4 kinases,PI4K

5-(4-(Methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine

MMV390048, 10 mM in DMSO

MMV390048 (MMV 048

1314883-11-8