KY 05009

Product Name: KY 05009
CAS No.: 1228280-29-2
Chemical Name: KY 05009
Synonyms: KY 05009;KY-05009 ，E2376;KY-05009 (KY05009;KY-05009 >=98% (HPLC);KY-05009, 10 mM in DMSO;TNIK Inhibitor, KY-05009;5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-[(4-methylbenzoyl)amino]-2-(phenylamino)-;5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide(WXC06259);KY-05009,plasma-cells,MAP4K,Apoptosis,TNIK,inhibit,anti-cancer,KY05009,Wnt,caspase-dependent,MAPK Kinase Kinase Kinase,anti-proliferative,IL-6,Inhibitor,smyeloma,aminothiazole,KY 05009
CBNumber: CB73146320
Molecular Formula: C18H16N4O2S
Formula Weight: 352.41
MOL File: 1228280-29-2.mol

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KY 05009 Property

storage temp.: 2-8°C
solubility: DMSO:76.67(Max Conc. mg/mL);217.54(Max Conc. mM)
form: powder
color: light yellow to dark yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1506
Product name: KY-05009
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $131
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1506
Product name: KY-05009
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $395
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.33298
Product name: TNIK Inhibitor, KY-05009
Packaging: 10 mg
Price: $215
Updated: 2025/07/31

Cayman Chemical

Product number: 29552
Product name: KY 05009
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29552
Product name: KY 05009
Packaging: 25mg
Price: $442
Updated: 2024/03/01

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KY 05009 Chemical Properties,Usage,Production

Uses

KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1].

Biochem/physiol Actions

KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.

IC 50

TNIK: 100 nM (Ki)

References

[1] Lee Y, et al. Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. Oncotarget. 2017 Jun 20;8(25):41091-41101. DOI:10.18632/oncotarget.17056

KY 05009 Preparation Products And Raw materials

Raw materials

Preparation Products

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KY 05009 Suppliers

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1228280-29-2, KY 05009Related Search:

KY 05009

5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide

5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide(WXC06259)

KY-05009 (KY05009

4-Thiazolecarboxamide, 5-[(4-methylbenzoyl)amino]-2-(phenylamino)-

KY-05009 >=98% (HPLC)

KY-05009,plasma-cells,MAP4K,Apoptosis,TNIK,inhibit,anti-cancer,KY05009,Wnt,caspase-dependent,MAPK Kinase Kinase Kinase,anti-proliferative,IL-6,Inhibitor,smyeloma,aminothiazole,KY 05009

KY-05009, 10 mM in DMSO

TNIK Inhibitor, KY-05009

KY-05009 ，E2376

1228280-29-2