KX2-391 (Mesylate)

Product Name: KX2-391 (Mesylate)
CAS No.: 1080645-95-9
Chemical Name: KX2-391 (Mesylate)
Synonyms: KX01 MESYLATE;KX2-391 (Mesylate);Tirbanibulin Mesylate;Tirbanibulin Mesylate, 10 mM in DMSO;2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide mesylate;KX01,KX2-391,Src,Tirbanibulin Mesylate,Inhibitor,inhibit,KX-01,Tirbanibulin,KX 01,Microtubule/Tubulin
CBNumber: CB73155063
Molecular Formula: C27H33N3O6S
Formula Weight: 527.63242
MOL File: 1080645-95-9.mol

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KX2-391 (Mesylate) Property

storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO : ≥ 57 mg/mL (108.03 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6000
Product name: Tirbanibulin(Mesylate)
Purity: 99.88%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-6000
Product name: Tirbanibulin(Mesylate)
Purity: 99.88%
Packaging: 10mg
Price: $95
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611849
Product name: KX2-391 mesylate
Packaging: 10mg
Price: $268.6
Updated: 2021/12/16

ChemScene

Product number: CS-6000
Product name: Tirbanibulin(Mesylate)
Purity: 99.88%
Packaging: 50mg
Price: $350
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611849
Product name: KX2-391 mesylate
Packaging: 50mg
Price: $579.7
Updated: 2021/12/16

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KX2-391 (Mesylate) Chemical Properties,Usage,Production

Uses

Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.

in vivo

Orally administered Tirbanibulin Mesylate (KX2-391 Mesylate) is shown to inhibit primary tumor growth and to suppress metastasis, in pre-clinical animal models of cancer^[2].

References

[1] Lau GM, et al. Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci, 2009, 54(7), 1465-1474. DOI:10.1007/s10620-008-0519-0
[2] Fallah-Tafti A, et al. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities. Eur J Med Chem, 2011, 46(10), 4853-4858. DOI:10.1016/j.ejmech.2011.07.050

KX2-391 (Mesylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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1080645-95-9, KX2-391 (Mesylate)Related Search:

Tirbanibulin Mesylate

KX01 MESYLATE

KX2-391 (Mesylate)

2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide mesylate

KX01,KX2-391,Src,Tirbanibulin Mesylate,Inhibitor,inhibit,KX-01,Tirbanibulin,KX 01,Microtubule/Tubulin

Tirbanibulin Mesylate, 10 mM in DMSO

1080645-95-9