7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL

Product Name: 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL
CAS No.: 747408-78-2
Chemical Name: 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL
Synonyms: PB 1033;PBT-1033, 10 mM in DMSO;7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL;5,7-Dichloro-2-((dimethylamino)methyl)quinolin-8-ol;8-Quinolinol,5,7-dichloro-2-[(dimethylamino)methyl]-
CBNumber: CB73163916
Molecular Formula: C12H12Cl2N2O
Formula Weight: 271.14
MOL File: 747408-78-2.mol

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7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Property

Boiling point:: 367.8±37.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (368.81 mM; Need ultrasonic)
form: Solid
pka: 7.26±0.28(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Chemical Properties,Usage,Production

Uses

PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].

in vivo

PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease^[5].

Animal Model:	Female Tg2576 mice^[5]
Dosage:	30 mg/kg/d
Administration:	Oral administration, 11 days
Result:	Increased hippocampal apical spine density, basal spine density.

References

[1] Faux NG, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20(2):509-16. DOI:10.3233/JAD-2010-1390
[2] Harbison-Price N, et al. Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2. mSphere. 2020 Mar 18;5(2):e00157-20.
[3] Johanssen T, et al. PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning. Neurobiol Dis. 2015 Sep;81:176-85. DOI:10.1016/j.nbd.2015.02.008
[4] Crouch PJ, et al. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem. 2011 Oct;119(1):220-30. DOI:10.1111/j.1471-4159.2011.07402.x
[5] Adlard PA, et al. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One. 2011 Mar 11;6(3):e17669. DOI:10.1371/journal.pone.0017669

7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Suppliers

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747408-78-2, 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OLRelated Search:

7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL

8-Quinolinol,5,7-dichloro-2-[(dimethylamino)methyl]-

PB 1033

5,7-Dichloro-2-((dimethylamino)methyl)quinolin-8-ol

PBT-1033, 10 mM in DMSO

747408-78-2