ChemicalBook > CAS DataBase List > LOXO-195
LOXO-195
- Product Name
- LOXO-195
- CAS No.
- 1350884-56-8
- Chemical Name
- LOXO-195
- Synonyms
- LOXO-195;LOXO-195(3aR);(6RS)-LOXO-195;LOXO195 R racemic;LOXO-195, 10 mM in DMSO;Selitrectinib Racemate;Selitrectinib(LOXO-195) Racemate;(18bR)-17-Fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-10H-5,7-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-10-one;12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR)-
- CBNumber
- CB73311672
- Molecular Formula
- C20H21FN6O
- Formula Weight
- 380.42
- MOL File
- 1350884-56-8.mol
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LOXO-195 Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- pka
- 11.44±0.40(Predicted)
- InChI
- InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12?,17-/m1/s1
- InChIKey
- OEBIHOVSAMBXIB-RGUGMKFQSA-N
- SMILES
- N12CCC[C@]1([H])C1=CC(F)=CN=C1CCC(C)NC(=O)C1C=NN3C=CC2=NC=13
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N-Bromosuccinimide Price
Usbiological
- Product number
- 453924
- Product name
- LOXO-195
- Packaging
- 1mg
- Price
- $496
- Updated
- 2021/12/16
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LOXO-195 Chemical Properties,Usage,Production
Description
LOXO-195 is an orally available, highly potent, and selective TRK kinase inhibitor designed to overcome drug resistance mediated by acquired mutations. Although responses to TRK inhibition can be dramatic and durable; however, eventually emergence of acquired resistance is found to be inevitable.
Uses
(3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].
References
[1] Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972. DOI:10.1158/2159-8290.CD-17-0507
LOXO-195 Preparation Products And Raw materials
Raw materials
Preparation Products
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LOXO-195 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80
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View Lastest Price from LOXO-195 manufacturers
Career Henan Chemical Co
- Product
- LOXO-195 1350884-56-8
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07