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N-Boc-piperidine-2-methanol

Product Name
N-Boc-piperidine-2-methanol
CAS No.
157634-00-9
Chemical Name
N-Boc-piperidine-2-methanol
Synonyms
tert-Butyl 2-(hydroxymethyl)piperidine-1-carboxylate;BOC-2-PIPERIDYLMETHANOL;1-Boc-2-piperidinemethanol;N-Boc-2-piperidinecarbinol;1-Boc-Piperidine-2-Methanol;n-boc-piperidine-2-methanol;1-N-Boc-2-piperidinemethanol;N-Boc-2 - piperidinyl alcohol;N-Boc-piperidine-2-Methanol 97%;1-BOC-2-HYDROXYMETHYL-PIPERIDINE
CBNumber
CB7340947
Molecular Formula
C11H21NO3
Formula Weight
215.29
MOL File
157634-00-9.mol
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N-Boc-piperidine-2-methanol Property

Melting point:
74-78 °C
Boiling point:
308.0±15.0 °C(Predicted)
Density 
1.059±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
pka
15.08±0.10(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-7-5-4-6-9(12)8-13/h9,13H,4-8H2,1-3H3
InChIKey
PZTAGFCBNDBBFZ-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCCCC1CO
CAS DataBase Reference
157634-00-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811
WGK Germany 
3
HazardClass 
IRRITANT
HazardClass 
6.1
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681296
Product name
N-Boc-piperidine-2-methanol
Purity
97%
Packaging
1g
Price
$94
Updated
2023/06/20
Sigma-Aldrich
Product number
681296
Product name
N-Boc-piperidine-2-methanol
Purity
97%
Packaging
10g
Price
$290
Updated
2023/06/20
TCI Chemical
Product number
B3755
Product name
1-(tert-Butoxycarbonyl)-2-piperidinemethanol
Purity
>97.0%(GC)
Packaging
5g
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
B3755
Product name
1-(tert-Butoxycarbonyl)-2-piperidinemethanol
Purity
>97.0%(GC)
Packaging
25g
Price
$200
Updated
2025/07/31
TRC
Product number
B701600
Product name
tert-Butyl2-(Hydroxymethyl)piperidine-1-carboxylate
Packaging
50mg
Price
$60
Updated
2021/12/16
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N-Boc-piperidine-2-methanol Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

Reactant for:

  • Julia coupling for synthesis of corydendramine A
  • Cyclization-functionalization of nitrogen-containing dienes

Reactant for synthesis of:
  • Heterocyclic compounds
  • Anthranilamide inhibitors of factor Xa
  • Human GnRH receptor antagonists
  • Sphingosine-1-phosphate receptor agonists

Synthesis

24424-99-5

3433-37-2

157634-00-9

The general procedure for the synthesis of 1-Boc-2-piperidinemethanol from di-tert-butyl dicarbonate and 2-piperidinemethanol is as follows: 1. 2-Piperidinemethanol (3.0 g, 25.60 mmol) was dissolved in dichloromethane (DCM, 100 mL) under stirring. 2. triethylamine (14.5 mL, 91.08 mmol) was added to the above solution in batches, followed by di-tert-butyl dicarbonate (7.2 g, 31.0 mmol). 3. The reaction mixture was stirred at room temperature for 16 hours. 4. Upon completion of the reaction, water (70 mL) was added for stratification to separate the organic layer. 5. The organic layer was washed with water (2 x 50 mL) and then dried with anhydrous sodium sulfate (Na2SO4). 6. The dried organic layer was filtered and concentrated under vacuum to give 1-Boc-2-piperidinemethanol (6.0 g, quantitatively) as a light brown oil, which can be used without further purification. The nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) data were as follows: δ 4.42-4.22 (1H, m), 4.05-3.91 (1H, m), 3.89-3.77 (1H, m), 3.71-3.53 (1H, m), 2.97-2.81 (1H, m), 2.32-2.08 (1H, m), 1.90 (1H, s ), 1.77-1.57 (3H, m), 1.54 (1H, s), 1.52-1.38 (10H, m).

References

[1] Patent: WO2007/141504, 2007, A1. Location in patent: Page/Page column 57
[2] Organic Letters, 1999, vol. 1, # 4, p. 667 - 670
[3] Journal of Organic Chemistry, 1996, vol. 61, # 17, p. 6040 - 6043
[4] Tetrahedron Asymmetry, 1998, vol. 9, # 11, p. 1951 - 1965
[5] Tetrahedron Letters, 2015, vol. 56, # 46, p. 6478 - 6483

N-Boc-piperidine-2-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-piperidine-2-methanol Suppliers

Americas 1 China 192 Europe 1 France 1 Germany 2 India 4 Italy 2 Japan 1 Switzerland 1 United Kingdom 6 United States 27 Global 238
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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View Lastest Price from N-Boc-piperidine-2-methanol manufacturers

Anhui Zhongda Biotechnology Co., Ltd
Product
N-Boc-piperidine-2-methanol 157634-00-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-10-24
Hebei Mingeng Biotechnology Co., Ltd
Product
N-Boc-piperidine-2-methanol 157634-00-9
Price
US $220.00/KG
Min. Order
10g
Purity
99%
Supply Ability
500kg/month
Release date
2021-12-14
Jinan Ande Pharmaceutical Co.,Ltd.
Product
N-Boc-piperidine-2-methanol 157634-00-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100
Release date
2022-02-26

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